Background : Pamidronate is used extensively for treatment of osteoporotic and high bone turnover conditions. As it has a long retention time in the human skeleton, concerns have been raised as to safety profile in women of child bearing age.

Methods: Four infant outcomes of pregnancies of three women, two with polyostotic fibrous dysplasia and one with osteogenesis imperfecta, all of whom were treated with intravenous pamidronate before conception, are reported, with biochemical, radiological and bone density data.

Results: Each pregnancy was uncomplicated and the four offspring are healthy with no evidence of biochemical or skeletal abnormality.

Conclusions: We found no evidence for adverse effects of pre-pregnancy pamidronate on maternal or fetal health. Until the results of systematic studies are available, caution is recommended regarding pamidronate use in women of child-bearing years.