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Submitted on October 28, 2005
Accepted on February 6, 2006
Institute of Endocrinology, University of Milan, Milan, Italy; Section of Endocrinology, Department of Biochemical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy; Radiotherapy Department, Malpighi Hospital, Bologna, Italy; Section of Endocrinology, Diabetes and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts
* To whom correspondence should be addressed. E-mail: elizabeth.pearce{at}bmc.org.
Context: The recognition of thyroid microcarcinoma has increased due to the widespread use of ultrasound guided fine needle aspiration biopsies (FNAB)
Objective: to describe histological and clinical characteristics of papillary thyroid microcarcinoma (PTMC) 
1 cm.
Design: Retrospective cohort
Setting: University hospital endocrine clinic
Patients: 243 consecutive patients with PTMC over a 9-year period.
Results: PTMC was an incidental finding at surgery in 21.4% of the PTMC cases. There were no differences in the clinical characteristics between those with incidental PTMC and those with suspected thyroid carcinoma. None of the patients with a cancer < 8 mm had distant metastases whereas distant metastases were observed in patients with cancers 
8 mm (P 0.05). Disease-related mortality was not observed.
Conclusions: PTMC is prevalent in the population. Among patients with PTMC, tumor size > 8 mm is associated with more aggressive disease.
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