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This version published online on January 31, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-1837
A more recent version of this article appeared on April 1, 2006
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Submitted on August 16, 2005
Accepted on January 20, 2006

CORTISTATIN-17 AND SOMATOSTATIN-14 DISPLAY THE SAME EFFECTS ON GH, PRL AND INSULIN SECRETION IN PATIENTS WITH ACROMEGALY OR PROLACTINOMA

S. Grottoli, V. Gasco, F. Broglio, R. Baldelli, F. Ragazzoni, F. Gallenca, A. Mainolfi, F. Prodam, G. Muccioli, and E. Ghigo*

Division of Endocrinology and Metabolism, Department of Internal Medicine; Department of Anatomy, Pharmacology and Forensic Medicine; University of Turin, ITALY

* To whom correspondence should be addressed. E-mail: ezio.ghigo{at}unito.it.

Context: Cortistatin binds all somatostatin receptor subtypes but has also particular central actions; moreover a specific cortistatin receptor has also been discovered.

Objective: We compared the endocrine effects of cortistatin-17 with those of somatostatin-14 in patients with acromegaly (ACRO) or prolactinoma (PRLOMA). Normal subjects (NS) were studied as control group.

Design: All subjects underwent the following tests: 1) saline; 2) somatostatin-14 (2.0 µg/kg/h i.v. 0'-120'); 3) cortistatin-17 (2.0 µg/kg/h i.v. 0'-120') infusion.

Results: Cortistatin-17 and somatostatin-14 inhibited GH secretion to the same extent in ACRO (P < 0.05) and NS (P < 0.01). Cortistatin-17 and somatostatin-14 inhibited PRL secretion in PRLOMA (P < 0.05), to some extent in ACRO (p =NS) but not in NS. Insulin secretion was inhibited by both cortistatin-17 and somatostatin-14 to the same extent in all groups (P < 0.05).

Conclusions: Cortistatin-17 and somatostatin-14 display the same effects on GH, PRL and insulin secretion in patients with acromegaly or prolactinoma.
Key words: cortistatin • somatostatin • GH • PRL • insulin • glucose • acromegaly • prolactinoma




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