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Submitted on August 11, 2005
Accepted on November 11, 2005
Twin Research & Genetic Epidemiology Unit, St Thomas' Hospital, London, SE1 7EH, UK Hypertension Research Centre, Department of Pediatrics, Hypertension research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, USA, Dept of Chemical Pathology, St Thomas' Hospital, London SE1 7EH
* To whom correspondence should be addressed. E-mail: avivab{at}umdnj.edu.
Context: Leukocyte telomere length is inversely correlated with age, insulin resistance, serum leptin and smoking.
Objective: We explored whether menopausal status modifies the relations between leukocyte telomere length and insulin resistance. In addition, we examined the effect of menopause on the relation between leukocyte telomere length and C-reactive protein (CRP), an index of inflammation.
Design: observational cohort study
Setting: community based.
Participants: 1517 women aged 18-79 selected only for belonging to a twin pair and representative of the general population.
Main outcome measure: Leukocyte telomere restriction fragment length (TRFL).
Results: Insulin resistance, (expressed in the homeostasis model assessment), leptin and CRP were inversely correlated with leukocyte TRFL in pre-menopausal but not postmenopausal women. Insulin resistance, CRP, but not leptin independently accounted for variation In WBC TRFL in pre-menopausal women.
Conclusions: Menopausal status impacts leukocyte telomere length and its relation with insulin resistance and inflammation in women.
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