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Submitted on August 8, 2005
Accepted on November 15, 2005
Department of Internal Medicine B, Department of Internal Medicine A, School of Dentistry, Institute of Epidemiology and Social Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany
* To whom correspondence should be addressed. E-mail: mdoerr{at}uni-greifswald.de.
Background: Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular events. Decreased serum TSH predicts vascular mortality, which hypothetically could be explained in part by alterations of the blood coagulation system.
Objective: To investigate the association between thyroid function and plasma fibrinogen levels in a general population.
Design: The population-based Study of Health in Pomerania (SHIP) was performed in a previously iodine-deficient area in Germany, including 4310 subjects aged 20 to 79 yr. Data of 3804 individuals without thyroid disease were analyzed. Analysis revealed an association between thyroid function status and plasma fibrinogen concentration.
Results: Elevated fibrinogen levels > 3.25 g/l were observed in 14 persons with increased serum TSH levels (32.6%), in 973 euthyroid persons (28.9%), in 158 persons with decreased serum TSH levels (40.7%), and in 6 individuals with overt hyperthyroidism (54.4%). Logistic regression analysis revealed decreased serum TSH as an independent risk factor for elevated fibrinogen levels (odds ratio 1.42, 95%-confidence interval 1.12-1.80).
Conclusions: Thyroid function is associated with plasma fibrinogen. Decreased serum TSH is an independent risk factor for elevated plasma fibrinogen levels as a possible explanation for a high cardiovascular mortality among affected subjects.
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