| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
Submitted on August 1, 2005
Accepted on January 10, 2006
Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen 
, Denmark; The Copenhagen City Heart Study, Bispebjerg University Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
* To whom correspondence should be addressed. E-mail: brno{at}herlevhosp.kbhamt.dk.
Context: Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD).
Objective: To investigate influence of T(-93)G, G(-53)C, Asp9Asn, Gly188Glu, Asn291Ser, and Ser447Ter lipoprotein lipase genotypes on triglycerides, HDL and IHD.
Design: 1)Cross-sectional: 9004 adults, 2)prospective: 8817 adults developing 1001 IHD events during 23 yr, 3)case-control: 7818 non-IHD individuals vs. cohorts of 915 and 1062 IHD patients, respectively.
Setting: Danish general population (The Copenhagen City Heart Study).
Participants: IHD was angina pectoris or myocardial infarction.
Main Outcome Measures: Triglycerides, HDL and IHD.
Results: Cross-sectionally, triglycerides varied by genotype with 1.27 mmol/L in women and 1.22 mmol/L in men. HDL cholesterol varied by genotype with 0.49 mmol/L in women and 0.60 mmol/L in men. Prospectively, 9Asn(with -93G) heterozygotes and homozygotes combined vs. non-carriers had a hazard ratio for IHD of 1.6(95%CI: 1.2-2.3); 291Ser and 447Ter did not change IHD risk. In case-control study, combining the cohorts of IHD patients, 9Asn(with -93G) heterozygotes and homozygotes combined vs. non-carriers had an odds ratio for IHD of 1.5(1.2-2.1). 291Ser and 447Ter did not change IHD risk. Stratified for apolipoprotein E genotype, odds ratios for IHD in 9Asn(with -93G) heterozygotes and homozygotes combined vs. non-carriers were 2.6(1.2-5.5) among 
32 individuals and 2.4(1.4-4.1) among 43 individuals.
Conclusions: Genetic variation in lipoprotein lipase associates with differences in plasma triglycerides >1 mmol/L and differences in HDL cholesterol >0.5 mmol/L. A 1.6-fold risk of IHD in 9Asn(with -93G) heterozygotes and homozygotes combined is influenced by apolipoprotein E genotype.
This article has been cited by other articles:
 |
|
 |
|
  G. S. Sagoo, I. Tatt, G. Salanti, A. S. Butterworth, N. Sarwar, M. van Maarle, J. W. Jukema, B. Wiman, J. J. P. Kastelein, A. M. Bennet, et al. Seven Lipoprotein Lipase Gene Polymorphisms, Lipid Fractions, and Coronary Disease: A HuGE Association Review and Meta-Analysis Am. J. Epidemiol., December 1, 2008; 168(11): 1233 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Frikke-Schmidt, B. G. Nordestgaard, M. C. A. Stene, A. A. Sethi, A. T. Remaley, P. Schnohr, P. Grande, and A. Tybjaerg-Hansen Association of Loss-of-Function Mutations in the ABCA1 Gene With High-Density Lipoprotein Cholesterol Levels and Risk of Ischemic Heart Disease JAMA, June 4, 2008; 299(21): 2524 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kathiresan, O. Melander, D. Anevski, C. Guiducci, N. P. Burtt, C. Roos, J. N. Hirschhorn, G. Berglund, B. Hedblad, L. Groop, et al. Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events N. Engl. J. Med., March 20, 2008; 358(12): 1240 - 1249. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
