help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on November 15, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-1672
A more recent version of this article appeared on February 1, 2006
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
91/2/401    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DRUET, C.
Right arrow Articles by LEVY-MARCHAL, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DRUET, C.
Right arrow Articles by LEVY-MARCHAL, C.

Submitted on July 27, 2005
Accepted on November 3, 2005

CHARACTERIZATION OF INSULIN SECRETION AND RESISTANCE IN TYPE 2 DIABETES OF ADOLESCENTS

Céline DRUET*, Nadia TUBIANA-RUFI MD, Didier CHEVENNE PhD, Odile RIGAL PhD, Michel POLAK MD, PhD, and Claire LEVY-MARCHAL MD

INSERM Unit 690, Robert Debré Hospital, Paris, France; Pediatric Endocrinology and Diabetes Unit, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, France; Service de Biochimie Hormonologie, Robert Debre Hospital, Assistance Publique-Hôpitaux de Paris, France; Pediatric Endocrinology, Diabetic Unit, INSERM EMI 0363, Hôpital des Enfants-Malades, Paris, France

* To whom correspondence should be addressed. E-mail: drucel{at}yahoo.fr.

Context: Type 2 diabetes (T2D) in obese children is an emerging problem, including in Europe. Its presentation at diagnosis very often differs from that in adults.

Objective: The objective of this study was to investigate the relative contribution of the two components of T2D: insulin resistance and insulin secretion, early in the history of the disease in adolescents.

Patients and Methods: Six obese adolescents with T2D were included 2 months to 4.3 yr after diagnosis (5 girls and 1 boy with a median age of 15.4 yr and a median BMI of 4.4 SD). Peripheral and hepatic insulin sensitivity was evaluated with euglycemic hyperinsulinemic (40 mU/m2/min) clamp. First phase insulin release was evaluated after intravenous glucose stimulation. Graded intravenous glucose infusion and arginine test were performed to measure insulin secretion.

Results: All patients showed decreased peripheral glucose uptake to the same extent. Five patients showed hepatic insulin resistance. First phase insulin release was very low in two patients. Three patients showed an exaggerated insulin response under graded glucose infusion and preserved secretion under arginine stimulation. Three other patients, with elevated fasting plasma glucose, demonstrated a very low insulin response under glucose stimulation and a low insulin response under arginine stimulation.

Conclusions: These data emphasize that, together with marked IR, the failure of {beta} cell function is a major component in the course of T2D in childhood.
Key words: children • insulin resistance • insulin secretion • type 2 diabetes




This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
S. Wiegand, K. Raile, T. Reinehr, S. Hofer, A. Nake, W. Rabl, R. W Holl, and on behalf of the DPV-Wiss Study Group
Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy.
Eur. J. Endocrinol., April 1, 2008; 158(4): 543 - 549.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. D. Salbe, R. S. Lindsay, C. B. Collins, P. A. Tataranni, J. Krakoff, and J. C. Bunt
Comparison of Plasma Insulin Levels after a Mixed-Meal Challenge in Children with and without Intrauterine Exposure to Diabetes
J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 624 - 628.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society