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Submitted on July 26, 2005
Accepted on October 17, 2005
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA 17033
Context: Adult women with polycystic ovary syndrome (PCOS) have an increased prevalence of the metabolic syndrome (MBS). The prevalence of MBS is also increasing in adolescents.
Objective: To test the hypothesis that the prevalence of MBS is increased in adolescent girls with PCOS compared with the general population and to determine the factors associated with an increased risk of the MBS in PCOS.
Design: Cross-sectional case-control study.
Setting: Academic medical centers with General Clinical Research Center.
Participants: Forty-nine adolescent girls with PCOS and 165 girls from the NHANES III adolescent population of similar age and ethnic background.
Main Outcome Measure: Prevalence of MBS according to currently proposed adolescent MBS criteria.
Results: Thirty-seven percent of adolescent girls with PCOS had MBS compared with 5% of NHANES III girls (P < 0.0001). None of the girls of normal BMI had MBS whereas 11% of overweight and 63% of obese girls with PCOS had MBS compared with 0% and 32% of NHANES III girls, respectively. Girls with PCOS were 4.5 times more likely to have MBS than age matched NHANES III girls after adjusting for BMI (OR 4.5, 95% CI 1.1 - 17.7; P = 0.03).
The odds of having the MBS were 3.8 times higher for every quartile increase in uT in girls with PCOS after adjusting for BMI and insulin resistance (OR 3.8, 95% CI 1.4-10.2, P = 0.008).
Conclusions: Adolescent girls with PCOS have a higher prevalence of MBS than the general adolescent population. Hyperandrogenemia is a risk factor for MBS independent of obesity and insulin resistance.
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