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Submitted on July 26, 2005
Accepted on October 13, 2005
MedStar Research Institute, Washington, DC Children's National Medical Center, Washington, DC BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom G116NT
* To whom correspondence should be addressed. E-mail: Mary.s.burnett-miller{at}medstar.net.
Context. Recently, resistin was found to be present in atherosclerotic lesions in apoE - mice. Resistin may be associated with inflammation and atherosclerosis in humans; however the role of resistin in human disease remains controversial.
Objective. To assess cross-sectional relationships of resistin with coronary heart disease (CHD).
Design, Setting and Participants. Blood samples from the third examination of the Strong Heart Study (SHS)- the largest study of CHD in American Indians were used. Cases- who had suffered previous myocardial infarction (MI) (n = 100)- were selected randomly from the three SHS sites and matched for study site and sex with controls who had no history of CVD (n = 100).
Main Outcome Measure: Coronary heart disease
Results. Resistin levels were higher in cases than controls (median [interquartile range]: 3.4 [2.5-4.7] vs. 2.8 [2.1-4.0] ng/mL, P = 0.003) and had univariate correlations with age (Spearman r=0.21, P < 0.002), fasting insulin (r=0.21, P = 0.003), insulin resistance by homeostasis model (r=0.22; P = 0.04), albumin:creatinine ratio (ACR: r=0.19, P = 0.01) and fibrinogen (r=0.34, P < 0.0001). Cases were more likely to have diabetes (Cases 67%; Controls 41%; P < 0.0001) but had similar BMI (Cases 31.4 ± 5.4; Controls 30.7 ± 6.3; P = 0.85). Resistin levels were higher in participants with established nephropathy (ACR>300 mg/g n = 26) compared with those with normo- (n = 122) or micro-albuminuria (n = 42: Figure). In multivariate analysis nephropathy (P = 0.0013) but not previous MI (P = 0.12) was significantly associated with resistin.
Conclusions. Resistin is not independently associated with CHD. Resistin is elevated in survivors of MI; however, this reflects a novel association of raised resistin with diabetic nephropathy.
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