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This version published online on December 6, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-1643
A more recent version of this article appeared on February 1, 2006
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Submitted on July 22, 2005
Accepted on November 28, 2005

Large Differences in Testosterone Excretion in Korean and Swedish Men is Strongly Associated with an UDP-Glucuronosyl Transferase 2B17 Polymorphism

Jenny Jakobsson*, Lena Ekström, Nobuo Inotsume, Mats Garle, Mattias Lorentzon, Claes Ohlsson, Hyung-Keun Roh, Kjell Carlström, and Anders Rane

Dept of Laboratory Medicine, Div. of Clinical Pharmacology, Karolinska Institutet at Karolinska University Hospital, SE-141 86 Stockholm, Sweden; Center for Bone Research at the Sahlgrenska Academy, Dept of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Göteborg, Sweden; Dept. of Internal Medicine, Division of Clinical Pharmacology, Inha University Hospital, Incheon, Korea, and Dept of Clinical Science, Div of Obstetrics and Gynecolgoy, Karolinska Hospital, 171 76 Stockholm, Sweden

* To whom correspondence should be addressed. E-mail: Jenny.Jakobsson{at}labmed.ki.se.

Context: The reproductive endocrinology in Asians and Caucasians is of great interest in view of large differences in prostate cancer rate and sensitivity to pharmacological male contraception. In addition, interpretation of certain anti-doping tests is confounded by inter-ethnic variation in androgen disposition.

UDP-glucuronosyl transferases have a key role in the homeostasis and metabolism of androgens. Recently a deletion polymorphism was detected in the UGT2B17 gene.

Objective: To evaluate the contribution of the UGT2B17 deletion polymorphism to the inter-individual and inter-ethnic variation of androgen metabolism and excretion.

Methods and Results: Urine from 122 Swedish and 74 Korean healthy men were analyzed for several androgen glucuronides including testosterone. The distribution of the natural logarithms of urinary testosterone concentrations showed a distinct bimodal pattern in both groups, suggesting a monogenic inheritance.

When the UGT2B17 genotypes were compared with urinary testosterone levels all of the individuals of the UGT2B17 homozygous del/del genotype had no or negligible amounts of urinary testosterone. The del/del genotype was 7 times more common in the Korean (66.7%) than in the Swedish population (9.3%). In addition, the Swedes had significantly higher levels of serum testosterone compared with the Koreans.

Conclusions: Our results show that the UGT2B17 polymorphism is strongly associated with the bimodal distribution of the testosterone excretion and also with the large differences in testosterone excretion between Koreans and Swedes.
Key words: UGT2B17 • Ethnic Variation • Testosterone glucuronidation • Urinary excretion




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