| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on July 6, 2005
Accepted on October 3, 2005
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands, Division of Reproductive Medicine, Department of Obstetrics & Gynaecology, VU University medical centre, Amsterdam, The Netherlands
* To whom correspondence should be addressed. E-mail: jm.vink{at}psy.vu.nl.
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. There is evidence for a genetic component in PCOS based on familial clustering of cases.
Objective: In the present study the heritability of PCOS was estimated.
Design/participants: Data from 1332 monozygotic twins (genetically identical) and 1873 dizygotic twins/singleton sisters of twins (who share on average 50% of their segregating genes) registered with The Netherlands Twin Register were used. PCOS was defined as less than 9 menstrual cycles and acne or hirsutism in agreement with the 2003 Rotterdam consensus.
Results: Results point to a strong contribution of familial factors to PCOS. The resemblance in MZ twin sisters (tetrachoric correlation = 0.71) for PCOS was about twice as large as in DZ twin and other sisters (tetrachoric correlation = 0.38). Univariate analyses point to strong contributions of genetic factors to the variance in PCOS. Next, a trivariate genetic analysis of oligomenorrhea, acne and hirsutism was carried out. This analysis confirmed that the familial component in PCOS is due to genetic factors.
Conclusions: This study demonstrated a large influence of genetic factors to the pathogenesis of PCOS, justifying the search for susceptibility genes.
This article has been cited by other articles:
 |
|
 |
|
  M.O. Goodarzi, J.F. Maher, J. Cui, X. Guo, K.D. Taylor, and R. Azziz FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome Hum. Reprod., December 1, 2008; 23(12): 2842 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Kevenaar, A. P.N. Themmen, A. J. van Kerkwijk, O. Valkenburg, A. G. Uitterlinden, F. H. de Jong, J. S.E. Laven, and J. A. Visser Variants in the ACVR1 gene are associated with AMH levels in women with polycystic ovary syndrome Hum. Reprod., October 14, 2008; (2008) den353v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Franks, L. J. Webber, M. Goh, A. Valentine, D. M. White, G. S. Conway, S. Wiltshire, and M. I. McCarthy Ovarian Morphology Is a Marker of Heritable Biochemical Traits in Sisters with Polycystic Ovaries J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3396 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 The ESHRE Capri Workshop Group Genetic aspects of female reproduction Hum. Reprod. Update, April 2, 2008; (2008) dmn009v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Kevenaar, J. S. E. Laven, S. L. Fong, A. G. Uitterlinden, F. H. de Jong, A. P. N. Themmen, and J. A. Visser A Functional Anti-Mullerian Hormone Gene Polymorphism Is Associated with Follicle Number and Androgen Levels in Polycystic Ovary Syndrome Patients J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1310 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Urbanek, S. Sam, R. S. Legro, and A. Dunaif Identification of a Polycystic Ovary Syndrome Susceptibility Variant in Fibrillin-3 and Association with a Metabolic Phenotype J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4191 - 4198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. O. Goodarzi, H. J. Antoine, and R. Azziz Genes for Enzymes Regulating Dehydroepiandrosterone Sulfonation Are Associated with Levels of Dehydroepiandrosterone Sulfate in Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2659 - 2664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Codner and H. F. Escobar-Morreale Hyperandrogenism and Polycystic Ovary Syndrome in Women with Type 1 Diabetes Mellitus J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1209 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Rosenfield Identifying Children at Risk for Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 787 - 796. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
