help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on August 30, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-1306
A more recent version of this article appeared on November 1, 2005
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
90/11/6035    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rey, R. A.
Right arrow Articles by Cassorla, F. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rey, R. A.
Right arrow Articles by Cassorla, F. G.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CHORIONIC GONADOTROPIN
*TESTOSTERONE

Submitted on June 13, 2005
Accepted on August 23, 2005

Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias

Rodolfo A. Rey*, Ethel Codner, Germán Iñíguez, Patricia Bedecarrás, Romina Trigo, Cecilia Okuma, Silvia Gottlieb, Ignacio Bergadá, Stella M. Campo, and Fernando G. Cassorla

Centro de Investigaciones Endocrinológicas, Hospital de Niños R. Gutiérrez, Buenos Aires, Argentina; Centro de Investigaciones en Reproducción, Departamento de Histología, Biología Celular, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, Argentina; Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile

* To whom correspondence should be addressed. E-mail: rodolforey{at}cedie.org.ar.

Context: Isolated hypospadias may result from impaired testicular function or androgen end-organ defects or, alternatively, from hormone-independent abnormalities of morphogenetic events responsible for urethral seam.

Objective: To evaluate the relative prevalence of hormone-dependent etiologies in boys with isolated hypospadias.

Design, Patients and Main Outcome Measures: We studied endocrine testicular capacity in 61 patients with isolated hypospadias and 28 with hypospadias associated with micropenis, cryptorchidism or ambiguous genitalia. Serum AMH and inhibin B were used as Sertoli cell markers. An hCG test was performed to evaluate Leydig cell function.

Results: Testicular dysfunction was observed in 57.1% and androgen end-organ defects in 7.2% of patients with hypospadias associated with cryptorchidism, micropenis or ambiguous genitalia. In the remaining 35.7%, the disorder was idiopathic. The presence of ambiguous genitalia predicted the existence of testicular or end-organ dysfunction with 81.8% specificity. Isolated hypospadias was associated in 14.8% of patients with testicular dysfunction, and in 6.5% of cases with end-organ defects; in 78.7% of cases, the condition was idiopathic. The occurrence of isolated hypospadias ruled out the existence of testicular or end-organ disorders with 80.0% sensitivity. Altogether our data indicate that the risk for the existence of an underlying testicular or end-organ dysfunction is low in patients with isolated hypospadias (OR = 0.13, 95% CI = 0.05-0.36, P < 0.001).

Conclusions: Boys with isolated hypospadias are more likely to have normal endocrine testicular and androgen end-organ functions, suggesting that transient disruption of morphogenetic events in early fetal life may be the predominant underlying cause.
Key words: Hypospadias • steroidogenesis • anti-Müllerian hormone • Müllerian inhibiting substance • inhibin • androgen insensitivity • 5{alpha}-reductase




This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
S. E. Recabarren, T. Sir-Petermann, R. Rios, M. Maliqueo, B. Echiburu, R. Smith, P. Rojas-Garcia, M. Recabarren, and R. A. Rey
Pituitary and Testicular Function in Sons of Women with Polycystic Ovary Syndrome from Infancy to Adulthood
J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3318 - 3324.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Codner, G. Iniguez, C. Villarroel, P. Lopez, N. Soto, T. Sir-Petermann, F. Cassorla, and R. A. Rey
Hormonal Profile in Women with Polycystic Ovarian Syndrome with or without Type 1 Diabetes Mellitus
J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4742 - 4746.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. A. Fowler, D. R. Abramovich, N. E. Haites, P. Cash, N. P. Groome, A. Al-Qahtani, T. J. Murray, and R. G. Lea
Human fetal testis Leydig cell disruption by exposure to the pesticide dieldrin at low concentrations
Hum. Reprod., November 1, 2007; 22(11): 2919 - 2927.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Crisosto, E. Codner, M. Maliqueo, B. Echiburu, F. Sanchez, F. Cassorla, and T. Sir-Petermann
Anti-Mullerian Hormone Levels in Peripubertal Daughters of Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2739 - 2743.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Sir-Petermann, E. Codner, M. Maliqueo, B. Echiburu, C. Hitschfeld, N. Crisosto, F. Perez-Bravo, S. E. Recabarren, and F. Cassorla
Increased Anti-Mullerian Hormone Serum Concentrations in Prepubertal Daughters of Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3105 - 3109.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society