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Submitted on May 18, 2005
Accepted on October 21, 2005
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging Intramural Research Program (NIA-IRP), National Institutes of Health (NIH), Baltimore, MD, USA; Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD, USA; Tuscany Regional Health Agency, Florence, Italy; Geriatric Rehabilitation, ASF-Florence, Italy; Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Italy; Advance Studies of Translational Research in Aging Unit, Clinical Research Branch, NIA-IRP, Baltimore, MD, USA
* To whom correspondence should be addressed. E-mail: ferruccilu{at}grc.nia.nih.gov.
Context: Age-associated decline in testosterone levels and an increase in pro-inflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear.
Objective: We hypothesized that testosterone and inflammatory markers are negatively correlated in older men.
Design: Cross sectional.
Setting: Population-based sample of older men.
Participants and measures: After excluding participants on glucocorticoids, antibiotics or those with recent hospitalization, 467 men aged 65 yr or older had complete data on total testosterone, bioavailable testosterone, sex-hormone binding globulin, albumin, interleukin-6, soluble interleukin-6 receptor, tumor necrosis factor-
, interleukin 1-
and C-reactive protein.
Results: After adjusting for potential confounders, soluble interleukin-6 receptor was significantly and inversely correlated with total testosterone (r0.20, P < 0.001), and bioavailable testosterone (r0.12, P < 0.05). Testosterone was not correlated with any other inflammatory marker.
Conclusions: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.
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