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This version published online on February 14, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-1062
A more recent version of this article appeared on May 1, 2006
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Submitted on May 12, 2005
Accepted on February 6, 2006

POSSIBLE ROLE OF ADIPONECTIN AND INSULIN SENSITIVITY IN MEDIATING THE FAVOURABLE EFFECTS OF LOWER BODY FAT MASS ON BLOOD LIPIDS

B Buemann*, A Astrup, O Pedersen, E Black, C Holst, S Toubro, S Echwald, J J Holst, C Rasmussen, and T I A Sørensen

Department of Human Nutrition. Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg, Denmark, Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark, Danish Epidemiology Science Centre, Institute for Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, DK 1357, Copenhagen K, Denmark, Panum Institute, University of Copenhagen, Blegdamsvej 3 2200 København N, Denmark; Faculty of Health Science, University of Aarhus, Aarhus, Denmark; Department of Human Nutrition. Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg, Denmark; Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark; Danish Epidemiology Science Centre, Institute for Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, DK 1357, Copenhagen K, Denmark; Panum Institute, University of Copenhagen, Blegdamsvej 3 2200 København N, Denmark; Faculty of Health Science, University of Aarhus, Aarhus, Denmark

* To whom correspondence should be addressed. E-mail: benjamins{at}email.dk.

Aims: To investigate the role of insulin sensitivity and serum adiponectin concentration as determinants, in middle aged men, of the relationship between lower body fat and blood lipids after truncal fat has been accounted for.

Methods: 443 men aged 39-65 yr, body mass index 18-43 kg/m2, participated in the study. The following variables were measured: regional body fat distribution as assessed by dual energy x-ray absorptiometry (DXA), VO2max, physical activity, fasting levels of serum adiponectin, triglycerides, and HDL- and total cholesterol. Plasma glucose and serum insulin were measured in the fasting state and after an oral glucose load.

Results: Lower-body fat mass was inversely associated with serum triglycerides and total cholesterol and positively with serum HDL-cholesterol after adjustment for age, lean tissue mass, truncal fat mass, weight history, VO2max, and the level of physical activity (P < 0.0005). Serum adiponectin level and Matsudas insulin sensitivity index were positively inter-correlated, and both were positively correlated to lower-body fat mass. When including adiponectin and insulin sensitivity in the analyses, the relationships between lower body fat mass and serum lipids were partly explained.

Conclusion: For a given level of truncal fat mass, a large lower-body fat mass is associated with an advantageous blood lipid profile, which may be partially mediated by the relationships to both insulin sensitivity and serum adiponectin level.
Key words: adiponectin • blood lipids • fat distribution • obesity • insulin sensitivity • lower-body fat • non-esterified fatty acids • triglycerides




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