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This version published online on January 4, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-1056
A more recent version of this article appeared on March 1, 2006
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Submitted on May 12, 2005
Accepted on December 27, 2005

INCREASED SERUM RESISTIN IN NONALCOHOLIC FATTY LIVER DISEASE IS RELATED TO LIVER DISEASE SEVERITY AND NOT TO INSULIN RESISTANCE

Claudio Pagano*, Giorgio Soardo, Catia Pilon, Carla Milocco, Lorenza Basan, Gabriella Milan, Debora Donnini, Diego Faggian, Michele Mussap, Mario Plebani, Claudio Avellini, Giovanni Federspil, Leonardo A. Sechi, and Roberto Vettor

Endocrine-metabolic laboratory, Dept. of Medical and Surgical Sciences, University of Padua, Italy, Liver Unit, Internal Medicine, Dept. of Pathology and Experimental and Clinical Medicine, University of Udine, Italy, Pathology Unit, University of Udine, Italy, Dept of Laboratory Medicine, University-Hospital of Padua, Italy

* To whom correspondence should be addressed. E-mail: claudio.pagano{at}unipd.it.

Context: The recently discovered hormone resitin is linked to the development of insulin resistance but direct evidence of resistin levels in humans with nonalcoholic fatty liver disease (NAFLD) is lacking.

Methods: We conducted this study to assess the relationship between serum resistin and NAFLD. We measured serum resistin, biochemical, hormonal and histological correlates in 28 NAFLD patients, 33 controls and 30 obese patients (BMI>30 kg/m2) without NAFLD.

Results: Resistin and adiponectin expression were measured in sc adipose tissue by qRT-PCR. Resistin was higher in NAFLD patients compared with control (5.87 ± 0.49 vs. 4.30 ± 0.20 ng/mL, P = 0.002) and obese patients (4.37 ± 0.27 ng/ml, P = 0.002). Increased resistin mRNA was found also in adipose tissue of NAFLD patients compared with controls and obese subjects.

Conclusions: Both NAFLD and obese patients had lower adiponectin while leptin was elevated only in the obese group. No correlation was found between resistin and hs-CRP, BMI, HOMA, insulin, glucose, transaminases and lipid values. A positive correlation was found between resistin and histological inflammatory score. These data report increased resistin in NAFLD patients which is related to histological severity of the disease, while do not support a link between resistin and insulin resistance or BMI in these patients.
Key words: adipokines • resistin • insulin resistance • metabolic syndrome • nonalcoholic fatty liver disease




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