help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on January 4, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-0950
A more recent version of this article appeared on March 1, 2006
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
91/3/820    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chellakooty, M
Right arrow Articles by Main, K M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chellakooty, M
Right arrow Articles by Main, K M

Submitted on April 29, 2005
Accepted on December 27, 2005

A prospective study of serum IGF-I and IGFBP-3 in 942 healthy infants: Associations with birth weight, gender, growth velocity and breastfeeding

M Chellakooty, A Juul, K A Boisen, I N Damgaard, C M Kai, I M Schmidt, J H Petersen, N E Skakkebæk, and K M Main*

University Department of Growth and Reproduction, Copenhagen University Hospital, and Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: katharina.main{at}rh.hosp.dk.

Context: Many aspects of hormonal regulation and mechanisms of normal infancy growth are poorly understood.

Objective: to establish determinants of serum growth factor levels in infancy and their association with growth

Design: prospective, longitudinal, population-based birth cohort 1997-2001

Participants: 942 healthy AGA infants (538 boys, 404 girls) and 49 SGA children (29 boys, 20 girls)

Interventions: anthropometrical measurements (0,3,18 and 36 months), serum sample (3 months)

Main Outcome Measures: Height, weight, serum IGF-I and IGFBP-3

Results: IGF-I levels showed no gender difference (boys 92 ng/ml (49, 162), girls 91 ng/ml (47, 149), P = 0.50). IGFBP-3 levels were significantly higher in females (2174 ng/ml [1295;3330] than in males (2103 ng/ml [1266;3143]), P = 0.04. Infants receiving breast milk had lower IGF-I levels (90 ng /ml (48, 154)), than infants receiving formula (n = 62) (97 ng/ml (58, 165)) or both (n = 123) (94 ng /ml (48, 169)), P < 0.001. IGF-I and IGFBP-3 levels were positively associated with weight gain and height gain from birth to 3 months of age in AGA, but not in SGA children. SGA children had significantly lower IGF-I (88.0 ng/ml (28, 145), P = 0.05) and IGFBP-3 levels (1835 ng/ml [1180;2793], P < 0.001) than AGA children.

Conclusion: We found a significant, but weak, association between IGF-I and IGFBP-3 levels at 3 months and postnatal growth in AGA, but not SGA children. Other factors than IGF-I must contribute to the regulation of normal postnatal growth, and these may differ between AGA and SGA children. IGFBP-3, but not IGF-I, showed a gender difference, which may reflect an influence of the postnatal activation of the pituitary-gonadal axis on binding protein levels.
Key words: IGF-I • IGFBP-3 • postnatal • growth




This article has been cited by other articles:


Home page
 PediatricsHome page
M. I. Klein, E. Bergel, L. Gibbons, S. Coviello, G. Bauer, A. Benitez, M. E. Serra, M. F. Delgado, G. A. Melendi, S. Rodriguez, et al.
Differential Gender Response to Respiratory Infections and to the Protective Effect of Breast Milk in Preterm Infants
Pediatrics, June 1, 2008; 121(6): e1510 - e1516.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. C. R. Prickett, B. Dixon, C. Frampton, T. G. Yandle, A. M. Richards, E. A. Espiner, and B. A. Darlow
Plasma Amino-Terminal Pro C-Type Natriuretic Peptide in the Neonate: Relation to Gestational Age and Postnatal Linear Growth
J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 225 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
P. Saenger, P. Czernichow, I. Hughes, and E. O. Reiter
Small for Gestational Age: Short Stature and Beyond
Endocr. Rev., April 1, 2007; 28(2): 219 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. Schack-Nielsen and K. F. Michaelsen
Advances in Our Understanding of the Biology of Human Milk and Its Effects on the Offspring
J. Nutr., February 1, 2007; 137(2): 503S - 510S.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Mau Kai, K. M. Main, A. Nyboe Andersen, A. Loft, M. Chellakooty, N. E. Skakkebaek, and A. Juul
Serum Insulin-Like Growth Factor-I (IGF-I) and Growth in Children Born after Assisted Reproduction
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4352 - 4360.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Iniguez, K. Ong, R. Bazaes, A. Avila, T. Salazar, D. Dunger, and V. Mericq
Longitudinal Changes in Insulin-Like Growth Factor-I, Insulin Sensitivity, and Secretion from Birth to Age Three Years in Small-for-Gestational-Age Children
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4645 - 4649.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2006 by The Endocrine Society