| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on March 17, 2005
Accepted on August 22, 2005
Karolinska Institutet, Clinical Research Center and Department of Medicine Karolinska University Hospital, Huddinge Stockholm, Sweden
* To whom correspondence should be addressed. E-mail: peter.arner{at}medhs.ki.se.
Context. Enlarged fat cells and leptin hypersecretion are hallmarks of common obesity.
Objective. To investigate fat cell size and leptin production in the basal state following long-term steady-state weight reduction to the non-obese state.
Design. Prospective case-control study. 3 ± 1 (mean ± SD) years duration.
Patients. Twenty-five obese women (cases). Each case was compared with a control subject matched for age, sex and BMI at nadir of weight for the cases.
Setting. University hospital.
Intervention. The subjects were followed until they reached a steady-state weight reduction following lifestyle modification or bariatric surgery (cases). Treatment target was the non-obese state (BMI< 30 kg/m2). sc adipose tissue secretion of leptin, serum leptin levels and fat cell volume were determined after an overnight fast.
Results Ten obese women (40%) reached the non-obese state. This was accompanied by marked decreases in fat cell volume, leptin secretion and serum leptin concentrations (P < 0.0001). The post-obese cases had 43% smaller fat cell volume (P = 0.0008), 68% lower adipocyte leptin production (P = 0.001) and 54% lower serum leptin levels (P = 0.0007) than control subjects, despite almost identical percentage body fat in the two groups. Fat cell volume, but not percentage body fat or BMI, was directly proportional to leptin secretion and serum leptin concentrations.
Conclusion. Adipose tissue hyperplasia (too many small fat cells) and low leptin production resulting in relative hypoleptinemia in the fasting (basal) state are common features of the post-obese state in women.
This article has been cited by other articles:
 |
|
 |
|
  M. R. Jackman, A. Steig, J. A. Higgins, G. C. Johnson, B. K. Fleming-Elder, D. H. Bessesen, and P. S. MacLean Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1117 - R1129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. E. Jocken, D. Langin, E. Smit, W. H. M. Saris, C. Valle, G. B. Hul, C. Holm, P. Arner, and E. E. Blaak Adipose Triglyceride Lipase and Hormone-Sensitive Lipase Protein Expression Is Decreased in the Obese Insulin-Resistant State J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2292 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Skurk, C. Alberti-Huber, C. Herder, and H. Hauner Relationship between Adipocyte Size and Adipokine Expression and Secretion J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1023 - 1033. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
