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This version published online on May 17, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-0537
A more recent version of this article appeared on September 1, 2005
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Submitted on March 10, 2005
Accepted on May 5, 2005

Height and height Z-score are related to calcium absorption in 5 to 15 yr-old girls

Steven A. Abrams MD*, Ian J. Griffin MB, ChB, Keli M. Hawthorne MS, RD, and Lily Liang MA

US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center; Department of Pediatrics, Sections of Nutrition and Neonatology, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas 77030

* To whom correspondence should be addressed. E-mail: sabrams{at}bcm.edu.

Context: Understanding the relationship between calcium absorption and growth has been limited. We have developed a database of calcium absorption measurements in 315 girls age 5.0-15.0 yr.

Design: We have used this database to assess the relationship between height, its age- and gender- normalized value (height Z-score), and calcium absorptive efficiency.

Results: Overall, height was significantly related to calcium absorption (corrected for calcium intake, age, Tanner, stage and ethnicity), P = 0.001. Similarly, height Z-score was significantly related to calcium absorption, P < 0.007. About 3-3.5% of the variability ({eta}-squared) of absorption was associated with height or height Z-score. We found that calcium absorption was significantly lower in girls with height Z-score ≤ 0 compared with those with a height Z-score > 0 (difference 3.9 ± 1.4%, mean ± SEM, P = 0.007). Limiting the analysis to those girls in which Tanner staging was performed or those ≥ 9 yr old did not substantively affect these relationships.

Conclusion: These results indicate that a small, but significant component of the variability in calcium absorption is due to height. Identifying genetic risk factors for lowered calcium absorption during growth could lead to individual approaches for prevention of inadequate bone mass.
Key words: Height • calcium absorption • stable isotopes • calcium metabolism




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