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This version published online on May 31, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-0437
A more recent version of this article appeared on August 1, 2005
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Submitted on February 28, 2005
Accepted on May 24, 2005

Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance

M. Gerber, A. Boettner, B. Seidel, A. Lammert, J. Bär, E. Schuster, J. Thiery, W. Kiess, and J. Kratzsch*

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Paul-List-Str.13-15, 04103 Leipzig; Hospital for Children and Adolescents, Faculty of Medicine, University of Leipzig, Oststr. 21-25, D 04317 Leipzig, Germany; Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Liebigstr. 16, D 04103 Leipzig, Germany; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Haertelstr. 16/18, D 04107 Leipzig, Germany

* To whom correspondence should be addressed. E-mail: kraj{at}medizin.uni-leipzig.de.

Objective: It was hypothesized that resistin links obesity with diabetes, but this has not been studied in children and adolescents to date. Patients: We determined serum resistin levels of 135 obese (BMI 32.0 ± 6.2, age 12.6 ± 3.4) and 201 lean children (BMI 18.7 ± 2.4, age 12.5 ± 2.5) by a newly developed and extensively evaluated in-house immunoassay. These results were controlled for their association with markers of puberty, obesity and insulin sensitivity.

Results: The analytical evaluation of our assay revealed different resistin isoforms with major peaks of higher than 660 kDa and 55 kDa in the size exclusion chromatography. Using this assay system we found no difference in the resistin levels of obese compared with lean subjects (P = 0.48). However, resistin was significantly higher in girls than in boys (6.74 ± 2.42 vs. 5.79 ± 2.45; P < 0.001). Interestingly, in both, obese and lean children, resistin correlated with age (P < 0.01), Tanner stage, testosterone and estradiol levels (P < 0.05). In contrast, no significant correlation was found with parameters of insulin resistance such as HOMA, ISI or insulin, proinsulin and glucose concentrations in obese subjects.

Conclusions: Resistin appears to be not the main link between obesity and insulin resistance in children and adolescents but due to its association with Tanner stage it may be related to the maturation of children during pubertal development. Additionally, we have demonstrated the presence of different molecular isoforms of resistin in human blood and this may raise problems in comparing data from diverse assay systems.
Key words: Resistin • puberty • obesity • insulin resistance • children




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