| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on January 4, 2005
Accepted on August 2, 2005
Dept of General Internal Medicine, Leiden University Medical Center, The Netherlands; Dept of Endocrinology and Metabolic diseases, Leiden University Medical Center, The Netherlands; Dept of Clinical Chemistry, Leiden University Medical Center, The Netherlands
* To whom correspondence should be addressed. E-mail: h.pijl{at}lumc.nl.
Context. Recent evidence implicates leptin as an important modulator of thyroid axis activity.
Objective. To study spontaneous 24 h TSH secretion and 24 h circulating leptin concentrations in obese and lean women.
Design. Prospective parallel study (2004).
Setting. Clinical Research Center LUMC.
Participants. 12 healthy obese premenopausal women (BMI 33.2 ± 0.9 kg/m2) and 11 lean controls (BMI 21.4 ± 0.5 kg/m2) were studied in the follicular phase of their menstrual cycle.
Intervention(s). None.
Main Outcome Measure(s). Spontaneous 24 h TSH concentrations (10 min time intervals) and secretion, calculated using waveform-independent deconvolution technique (Pulse). 24 h circulating leptin concentrations (20 min time intervals).
Results. Mean TSH concentration (obese 1.9 ± 0.2 vs. lean 1.1 ± 0.1 mU/L, P = 0.009) and secretion rate (obese 43.4 ± 5.5 vs. in lean 26.1 ± 2.2 mU/liter distribution volume. 24 h, P = 0.011) were substantially enhanced in obesity, whereas the fasting free thyroxine concentrations were similar (free T4 in obese 15.4 ± 1.5 vs. in lean 16.4 ± 1.5 pmol/L, P = 0.147). TSH secretion was positively related to 24 h leptin concentrations (R2 = 0.31, P = 0.007).
Conclusions. TSH release is enhanced in the face of normal plasma free thyroxine concentrations in obese premenopausal women and hyperleptinemia may well be involved in this neuroendocrine alteration.
This article has been cited by other articles:
 |
|
 |
|
  F. Roelfsema, P. Kok, M. Frolich, A. M. Pereira, and H. Pijl Disordered and Increased Adrenocorticotropin Secretion with Diminished Adrenocorticotropin Potency in Obese in Premenopausal Women J. Clin. Endocrinol. Metab., August 1, 2009; 94(8): 2991 - 2997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kok, F. Roelfsema, M. Frolich, J. van Pelt, A. E. Meinders, and H. Pijl Bromocriptine Reduces Augmented Thyrotropin Secretion in Obese Premenopausal Women J. Clin. Endocrinol. Metab., April 1, 2009; 94(4): 1176 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Roelfsema, A. M. Pereira, D. M. Keenan, J. D. Veldhuis, and J. A. Romijn Thyrotropin Secretion by Thyrotropinomas Is Characterized by Increased Pulse Frequency, Delayed Diurnal Rhythm, Enhanced Basal Secretion, Spikiness, and Disorderliness J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 4052 - 4057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Weiss and R. L. Brown Doctor . . . Could It Be My Thyroid? Arch Intern Med, March 24, 2008; 168(6): 568 - 569. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ortega, N. Pannacciulli, C. Bogardus, and J. Krakoff Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons Am. J. Clinical Nutrition, February 1, 2007; 85(2): 440 - 445. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
