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This version published online on September 27, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-2438
A more recent version of this article appeared on December 1, 2005
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Submitted on December 13, 2004
Accepted on September 15, 2005

Circulating Levels of Oxidative Stress Markers and Endothelial Adhesion Molecules in Men With Abdominal Obesity

CHARLES COUILLARD*, GUILLAUME RUEL, W. ROODLY ARCHER, SONIA POMERLEAU, JEAN BERGERON, PATRICK COUTURE, BENOIT LAMARCHE, and NATHALIE BERGERON

Institute of Nutraceuticals and Functional Foods (C.C., G.R., W.R.A., S.P., P.C., B.L.) and Department of Food Sciences and Nutrition (C.C., B.L., N.B.) Laval University, Québec, Canada G1K 7P4; and the Lipid Research Center, Laval University Medical Center (J.B., P.C.) Québec, Canada G1V 4G2

* To whom correspondence should be addressed. E-mail: charles.couillard{at}inaf.ulaval.ca.

Context. It has been suggested that oxidative stress and endothelial dysfunction could play a role in the higher cardiovascular disease (CVD) risk noted in the abdominally obese population.

Objective. Describe the associations between abdominal fat accumulation, oxidative stress and endothelial dysfunction in men.

Design. A complete physical and metabolic profile was assessed in a group of 56 men covering a wide range of adiposity and plasma oxidized LDL (OxLDL) and soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin and C-reactive protein (CRP) concentrations were determined.

Results. We found that waist circumference and visceral adipose tissue (AT) were positively associated with plasma OxLDL (r = 0.52, P < 0.0001) and CRP (r = 0.60, P < 0.0001) concentrations. We also found significant associations between plasma E-selectin levels and hyperinsulinemia (r = 0.39, P < 0.005) as well as with the homeostasis model assessment index of insulin resistance (HOMA-IR; r = 0.42, P < 0.005).

Conclusions. Our study showed that plasma OxLDL levels and low-grade systemic inflammation are increased in men with a high visceral AT accumulation. Furthermore, our results support the notion that insulin resistance is associated with endothelial activation. Overall, our observations give us further insights on the increased CVD risk frequently noted among viscerally obese-insulin resistant individuals.
Key words: Oxidative stress • endothelial dysfunction • visceral obesity • cardiovascular disease




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