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Submitted on November 11, 2004
Accepted on March 23, 2005
Department of Clinical and Experimental Medicine University Federico II, Naples, Italy
* To whom correspondence should be addressed. E-mail: bcapaldo{at}unina.it.
This study investigates whether acute, short-term hyperglycemia (H) affects coronary vasodilatory function in healthy subjects. Diastolic peak flow velocity in the left anterior descending coronary artery was measured at rest and after dipyridamole (0,56 mg/Kg over 4 min) using transthoracic color- Doppler ecocardiography in 13 healthy men. Coronary flow reserve (CFR) was defined as the ratio of dipyridamole-induced coronary peak diastolic to resting peak diastolic flow velocity. CFR was measured both in euglycemia (E) and after 3 h H (
14 mmol/L) by a variable infusion of glucose and octreotide (0.4 mg/h) to prevent increase in insulin concentration. Fasting plasma glucose increased to 14.3 ± 0.33 mmol/L during the study and maintained variability within < 10%. Plasma insulin remained nearly stable during H. Resting diastolic flow velocity was 18.5 ± 0.6 cm/sec in E and increased to 20.0 ± 0.7 cm/sec during H (P < 0.005). Dipyridamole infusion produced a marked increase in coronary flow velocity, which reached values of 50.8 ± 2.9 cm/sec in E and 51.8 ± 2.1 cm/sec in H (P = ns). CFR was 2.78 ± 0.16 in E and 2.59 ± 0.12 in H (P = ns). Our study indicates that short-term hyperglycemia does not affect the vasodilatory response of coronary microcirculation in healthy subjects.
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