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This version published online on March 29, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-2128
A more recent version of this article appeared on June 1, 2005
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Submitted on October 29, 2004
Accepted on March 17, 2005

Treatment with Growth Hormone and LHRH Analogue Improves Final Adult Height in Children with Congenital Adrenal Hyperplasia

Karen Lin-Su, Maria G. Vogiatzi, Ian Marshall, Madeleine D. Harbison, Maria C. Macapagal, Brian Betensky, Susan Tansil, and Maria I. New*

Department of Pediatrics, Mount Sinai School of Medicine, New York, NY; Department of Pediatric Endocrinology, Weill Medical College of Cornell University, New York, NY; Department of Pediatric Endocrinology, Robert Wood Johnson Medical School, New Brunswick, NJ

* To whom correspondence should be addressed. E-mail: maria.new{at}mssm.edu.

Final adult height is often compromised in children with congenital adrenal hyperplasia (CAH). This study examines the impact of growth hormone (GH) and LHRH analog (LHRHa) on final adult height in patients with CAH due to 21-hydroxylase deficiency. Fourteen patients with CAH (8 males, 6 females) predicted to be more than 1.0 SD below their mid-parental target height received GH and LHRHa until final height. Each patient was matched at the start of GH therapy to a CAH patient treated only with glucocorticoids according to type of CAH, sex, and chronological age. Mean age, bone age, height, height prediction, and target height were the same in both groups at the beginning of GH therapy. Mean duration of growth hormone treatment was 4.4 ± 1.5 yr. Mean duration of LHRHa therapy was 4.2 ± 2.0 yr. In the treatment group, final height SDS of -0.4 + 0.8 was significantly greater than both the initial prediction of -1.5 ± 0.9 (P < 0.0001) and the final height SDS of the untreated group of -1.4 ± 1.1 (P = 0.01). Our results indicate that the combination of GH and LHRHa improves final adult height in patients with CAH.




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