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Submitted on October 22, 2004
Accepted on December 10, 2004
Maternal and Child Health Sciences, University of Dundee, Dundee DD1 9SY Scotland UK; Department of Internal Medicine, Erasmus University Medical School, PO Box 1738, 3000 DR Rotterdam, The Netherlands; Nuclear Medicine Service, VA Medical Center, University of California - Irvine Medical Center, Long Beach, CA 90822-5201; Community Health Sciences, University of Dundee, Dundee DD1 9SY Scotland UK
* To whom correspondence should be addressed. E-mail: r.hume{at}dundee.ac.uk.
The purpose of this study was to relate severity of illness at 1, 7, 14 and 28 postnatal days in preterm infants groups, 23-27 (n = 73), 28-30 (n = 160) and 31-34 (n = 208) weeks gestation, to the corresponding sera levels of T4, FT4, TBG, TSH, T3, rT3 and T4S. The British Association of Perinatal Medicine and Neonatal Nurses Association 1992 scoring categories (Arch Dis Child. 67: 868-869) were used as an index of illness severity: Level 1 (maximal intensive care) was compared with Level 2 (high dependency intensive care) combined with Level 3 (special care); infants were scored on 1, 7, 14 and 28 postnatal days. In Level 1 infants there were significant reductions in: T3 at 7 days (28-30 weeks), 14 and 28 days (23-27 and 28-30 week); T4 at 7,14 and 28 days (23-27 weeks); at 14 and 28 days (28-30 weeks); and at day 7 (31-34 weeks); FT4 at 14 days (23-27 weeks). TSH was unchanged in all groups at all ages and with reductions in T4 and T3 being the key features of severe illness in extreme preterm infants.
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