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This version published online on February 15, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-2027
A more recent version of this article appeared on May 1, 2005
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Submitted on October 14, 2004
Accepted on February 3, 2005

Lipoprotein-associated phospholipase A2 (Lp-PLA2), a novel inflammatory biomarker and independent risk predictor for cardiovascular disease

Krishnankutty Sudhir MD, PhD, FRACP, FACC*

Consulting Associate Professor of Medicine, Stanford University Medical Center, Stanford, CA

* To whom correspondence should be addressed. E-mail: ksudhir{at}cvmed.stanford.edu.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 superfamily, a family of enzymes that hydrolyze phospholipids. Circulating Lp-PLA2 is a marker of inflammation that plays a critical role in atherogenesis; its inhibition may have antiatherogenic effects. Epidemiological data have consistently demonstrated the association of increased levels of Lp-PLA2 with increased risk of CHD. In general, studies from the WOSCOPS, MONICA and Rotterdam cohorts have shown that the association of Lp-PLA2 with CHD is not attenuated upon multivariate analysis with traditional risk factors and other inflammatory markers. In addition, in the ARIC cohort, Lp-PLA2 was particularly useful in identifying CHD risk among patients with a baseline LDL <130 mg/dL. Studies in subjects with CAD have also shown associations between Lp-PLA2 and cardiovascular risk. Polymorphisms of the Lp-PLA2 gene have been reported, with varying significance in Japanese and Caucasian populations. Overall, epidemiological studies suggest that measurement of Lp-PLA2 in plasma may be a useful in identifying individuals at high risk for cardiac events.
Key words: Inflammation • vascular • cardiovascular risk • coronary • stroke




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