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This version published online on December 28, 2004
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-1978
A more recent version of this article appeared on April 1, 2005
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*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Organ Transplantation
*Osteoporosis
Hazardous Substances DB
*PARATHYROID HORMONE

Submitted on October 6, 2004
Accepted on December 20, 2004

Clinical Review: Osteoporosis following solid organ transplantation

Naim M. Maalouf M. D. and Elizabeth Shane M. D.*

Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.; Department of Medicine, Columbia-Presbyterian Medical Center and College of Physicians and Surgeons, Columbia University, New York, New York, U.S.A.

* To whom correspondence should be addressed. E-mail: es54{at}columbia.edu.

With the rapid increase in the number of organs transplanted worldwide and the improved survival of transplant recipients, osteoporosis has emerged as a frequent complication of the transplantation process. In the past decade, the wider recognition of transplantation-related osteoporosis has led to a decrease in the risk of fracture for the individual patient. Nonetheless, fracture rates remain unacceptably high in transplant recipients. This presentation reviews the epidemiology of transplantation-related osteoporosis, the factors contributing to the pathogenesis of this complication, and the evaluation, prevention and treatment options that are available for kidney, liver, lung and heart transplant recipients.
Key words: Osteoporosis • transplantation • fracture • bone mineral density




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