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Submitted on September 21, 2004
Accepted on November 23, 2004
Department of Endocrinology and Metabolism, National Center for Child Health and Development (T.T., N.M.), Tokyo 157-8535; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba (H.N.), Chiba 260-8670; Department of Pediatrics, Asahikawa Medical College (K.F.), Asahikawa 078-8510; Division of Endocrinology and Metabolism, Kanagawa Children's Medical Center (K.T.), Yokohama 232-8555; Department of Clinical Nursing and Pediatrics, Faculty of Medicine, University of Yamanashi (K.O.), Yamanashi 409-3898; Department of Pediatrics, School of Medicine, Toho University (M.S.), Tokyo 143-8540; Department of Obstetrics and Gynecology, Graduate School of Medicine, University of Tokyo (K.K.), Tokyo 113-0033, Japan
* To whom correspondence should be addressed. E-mail: tanaka-t{at}ncchd.go.jp.
We evaluated the effect of leuprorelin treatment on adult height (AH) and followed recovery of reproductive function in 63 girls and 13 boys with central precocious puberty (CPP). Mean treatment durations were 3.8 ± 2.0 and 4.1 ± 2.5 yr, and post-treatment follow-up durations 3.5 ± 1.3 and 2.6 ± 1.1 yr for girls and boys, respectively. AH was 154.5 ± 5.7 cm for girls, and 89.5% of girls reached AH within their target height (TH) range. For boys, AH was 163.2 ± 13.0 cm and 90.9% reached TH range. It appeared that the Bayley-Pinneau method modified for Japanese children using a table for advanced bone age (BA) overestimated AH in CPP, and this method using a table for average BA and projected height for BA were suitable for prediction of AH in CPP.
Menarche or re-menarche occurred in 96.8% of girls at the age of 13.1 ± 1.5 yr. Of 11 girls who contributed urine samples, all 7 idiopathic and 2 organic cases were considered to have ovulation. Serum testosterone levels reached normal adult level in all boys.
In conclusion, long-term leuprorelin treatment for children with CPP improved AH and had no adverse effects on recovery of reproductive function.
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  A. M. Pasquino, I. Pucarelli, F. Accardo, V. Demiraj, M. Segni, and R. Di Nardo Long-Term Observation of 87 Girls with Idiopathic Central Precocious Puberty Treated with Gonadotropin-Releasing Hormone Analogs: Impact on Adult Height, Body Mass Index, Bone Mineral Content, and Reproductive Function J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 190 - 195. [Abstract] [Full Text] [PDF]
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