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Submitted on September 15, 2004
Accepted on January 17, 2005
VA Medical Center and University of Minnesota, Minneapolis, MN (KEE, HF); California Pacific Medical Center Research Institute, San Francisco, CA (RF); University of California, San Diego, CA (EBC) University of Pittsburgh, Pittsburgh, PA (JAC); Stanford University, Palo Alto, CA (MLS); University of Alabama, Birmingham, AL (CL); and Oregon Health and Science University, Portland, OR (EO)
* To whom correspondence should be addressed. E-mail: ensru001{at}umn.edu.
To test the hypothesis that weight loss in older men is associated with increased rates of hip bone loss irrespective of adiposity and intention to lose weight, we measured body weight, body composition, hip bone mineral density (BMD) and intention to lose weight in a cohort of 1,342 older men enrolled in the Osteoporotic Fractures in Men (MrOS) study and followed them prospectively for an average of 1.8 yr for changes in weight and BMD. The adjusted average rate of change in total hip BMD was 0.1% per year in men with weight gain, -0.3% per year in men with stable weight and -1.4% per year in men with weight loss (P for trend < 0.001). Higher rates of hip bone loss were observed in men with weight loss irrespective of category of body mass index, body composition, or intention to lose weight. Even among obese (body mass index 
30kg/m2) men trying to lose weight, those with documented voluntary weight reduction experienced an increase in hip bone loss (average rate of change in total hip BMD 0.5% per year in those with weight gain, -0.1% per year in those with stable weight and -1.7% per year in those with weight loss, P for trend < 0.001). Older men who experience weight loss have increased rates of hip bone loss, even among overweight and obese men undergoing voluntary weight reduction.
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