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Submitted on September 8, 2004
Accepted on October 20, 2004
Division of Endocrinology and Metabolism (K.M.C, K.W.L, N.H.K., S.G.K., D.S.C., S.H.B.), Division of Cardiology (C.G.P, H.S.S, D.J.O.), Department of Internal Medicine, Korea University, Seoul, Korea
* To whom correspondence should be addressed.
K. M. Choi, E-mail: medica7{at}korea.ac.kr
We examined the prevalence of an impaired glucose metabolism and its association with inflammation and insulin resistance in acute myocardial infarction (AMI) patients without a previous diagnosis of diabetes. This prospective study enrolled 52 AMI patients and 75 g oral glucose tolerance testing was performed on 30 patients at discharge and again 3 months later. We also measured serum adiponectin, high-sensitive C-reactive protein (hsCRP), and interleukin-6 (IL-6) on both occasions. Data were compared with those of 30 type 2 diabetic patients without a history of AMI. 40.0% and 36.7% of AMI patients had impaired glucose tolerance (IGT) at discharge and at 3 months, respectively. The corresponding proportions for newly diagnosed diabetes are 33.0% and 30.0%. At discharge, AMI patients with IGT or diabetes showed higher hsCRP and IL-6 levels compared with AMI patients with normal glucose tolerance (NGT) or control type 2 diabetic patients. Furthermore, AMI patients with IGT or diabetes exhibited higher insulin resistance and lower serum adiponectin levels than AMI patients with NGT at 3 months after discharge. Previously undiagnosed diabetes and IGT are common in Korean patients with AMI. These glycometabolic abnormalities are associated with inflammation, insulin resistance, and serum adiponectin levels.
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