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Submitted on August 2, 2004
Accepted on February 22, 2005
Divisions of Endocrinology, Department of Medicine and Pediatrics and the General Clinical Research Center, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, 1000 W Carson Street, Torrance, CA 90509, UCLA Olympic Analytical Laboratory, 2122 Granville Avenue, Los Angeles, CA 90025and The Center for Human Nutrition, 900 Veteran Avenue, Los Angeles, CA 90095-1742
* To whom correspondence should be addressed. E-mail: wang{at}gcrc.rei.edu.
To validate our hypothesis that reduction in dietary fat may result in changes in androgen metabolism, 39 middle-aged white, healthy men (50 to 60 yr) were studied while they were consuming their usual high fat, low fiber diet and after 8 weeks modulation to an isocaloric low fat, high fiber diet. Mean body weight decreased by 1 Kg whereas total caloric intake, energy expenditure and activity index were not changed. After diet modulation, mean serum testosterone (T) concentration fell (P < 0.0001) accompanied by small but significant decreases in serum free testosterone (P = 0.0045), 5 
dihydrotestosterone (DHT, P = 0.0053), and adrenal androgens (Androstendione, P = 0.0135; DHEA-S, P = 0.0011). Serum estradiol and sex hormone binding globulin showed smaller decreases. Parallel decreases in urinary excretion of some testicular and adrenal androgens were demonstrated. Metabolic clearance rates of T were not changed and production rates of T showed a downward trend while on low fat diet modulation. We conclude that reduction in dietary fat intake (and increase in fiber) results in 12% consistent lowering of circulating androgens levels without changing the clearance.
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