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This version published online on December 14, 2004
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-1501
A more recent version of this article appeared on March 1, 2005
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Submitted on July 29, 2004
Accepted on December 2, 2004

Insulin-like growth factor binding protein-1 is independently affected by ethnicity, insulin sensitivity and leptin in healthy, glucose-tolerant young men

CHOON F. LIEW, STEPHEN D. WISE, KWEE P. YEO, and KOK O. LEE*

Department of Medicine (C.F.L., K.O.L.), National University Hospital, Singapore 119074; and Lilly-NUS Centre for Clinical Pharmacology (S.D.W., K.P.Y.), National University of Singapore 117597

* To whom correspondence should be addressed. E-mail: mdcleeko{at}nus.edu.sg.

We examined the relationships between IGFBP-1, insulin sensitivity and leptin in different ethnic groups (Asian Indians, Chinese and Caucasians) using the euglycaemic hyperinsulinemic clamp. Ten healthy, young and non-diabetic subjects of each ethnic group, matched for body mass index (BMI), age and physical activity were studied. A euglycemic clamp was performed on all subjects. IGFBP-1, insulin and leptin were measured fasting and during the clamp. Fasting IGFBP-1 concentration was highest in Chinese (P = 0.027). Asian Indians had the lowest insulin sensitivity index (P = 0.006). The ratio of insulin to IGFBP-1 at fasting and throughout the euglycemic clamp was higher in Asian Indians. Fasting IGFBP-1 had a strong negative correlation with fasting leptin levels (r = - 0.715, P = 0.001). Multiple linear regression demonstrated that fasting insulin, leptin, ethnicity and insulin sensitivity were significant predictors for fasting IGFBP-1. IGFBP-1 is independently determined by ethnicity, insulin sensitivity and leptin in glucose-tolerant men. The presence of relative insulin resistance and low fasting IGFBP-1 levels in Asian Indians may contribute to their higher risk of developing diabetes and cardiovascular disease.




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