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This version published online on October 27, 2004
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-1430
A more recent version of this article appeared on January 1, 2005
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*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Steroids

Submitted on July 22, 2004
Accepted on October 15, 2004

Glucocorticoids decrease TRH mRNA expression in the paraventricular nucleus (PVN) of the human hypothalamus

A. Alkemade*, U. A. Unmehopa, W. M. Wiersinga, D. F. Swaab, and E. Fliers

Netherlands Institute for Brain Research, Amsterdam, The Netherlands, Department of Endocrinology and Metabolism, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands

* To whom correspondence should be addressed.
A. Alkemade, E-mail: a.alkemade{at}nih.knaw.nl

The way glucocorticoids affect TSH-releasing hormone TRH mRNA expression in the paraventricular nucleus (PVN) of the hypothalamus is still unclear. In view of its relevance for Cushing's syndrome and depression we measured TRH mRNA expression in human hypothalami obtained at autopsy by means of quantitative TRH mRNA in situ hybridization. In corticosteroid treated subjects (n = 10), TRH mRNA hybridization signal was decreased as compared with matched control subjects (n = 10)(Mann-Whitney U, P = 0.02). By inference, hypercortisolism as present in patients with Cushing's syndrome or major depression may contribute to lower serum TSH or to symptoms of depression by lowering hypothalamic TRH expression.
Key words: T3 • T4 • thyroid hormone • TSH • corticosteroids






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