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Submitted on July 15, 2004
Accepted on December 6, 2004
3rd Department of Medicine, Department of Sports Medicine and Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
* To whom correspondence should be addressed. E-mail: mhalu{at}lf1.cuni.cz.
To study the role of adipose tissue-derived hormones in the patophysiology of eating disorders, circulating levels of adiponectin, resistin and other hormonal and metabolic parameters were measured in 16 females with restrictive subtype of anorexia nervosa (R-AN), 10 females with binge/purge subtype of anorexia nervosa (P-AN), 15 females with bulimia nervosa (BN) and 12 age-matched healthy females (C). Body mass index (BMI), body fat content and serum leptin levels were severely decreased in R-AN and moderately decreased in P-AN patients, while BN group did not differ from C in these parameters. Serum soluble leptin receptor levels were increased in R-AN and P-AN and unchanged in BN patients. Circulating adiponectin levels were inversely related to BMI and were unchanged in BN patients, increased by 53% in P-AN and by 96% in R-AN relative to C group, respectively. In contrast, resistin levels in malnourished R-AN and P-AN were not different from either C or BN groups and showed no significant relationship to BMI or body fat content. We suggest that increased adiponectin levels reflect decreased body fat content AN patients. In contrast circulating resistin levels do not appear to be closely related to the nutritional status.
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