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This version published online on October 27, 2004
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-1230
A more recent version of this article appeared on January 1, 2005
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Submitted on June 28, 2004
Accepted on October 15, 2004

Correlation between the anti-inflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function

Abeda Mulla, Carel LeRoux, Egle Solito, and Julia C. Buckingham*

Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, and Department of Metabolic Medicine, Division of Investigative Sciences, Imperial College London, Hammersmith Campus, Du Cane Road London W12 0NN, United Kingdom

* To whom correspondence should be addressed.
Julia C. Buckingham, E-mail: j.buckingham{at}imperial.ac.uk

Annexin 1 (ANXA1), a Ca2+ and phospholipid binding protein, is an important mediator of the anti-inflammatory actions of glucocorticoids (GCs). However, although inflammatory responses in man are sensitive to alterations in adrenocortical function, the relationship between endogenous cortisol and ANXA1 expression has not been explored. Accordingly, we have measured serum cortisol levels and ANXA1 expression in peripheral blood leukocytes from subjects with normal and dysregulated cortisol secretion before and 30 min after a standard corticotrophin (ACTH) test. Our data demonstrate a highly significant correlation between the serum cortisol concentration and the expression of ANXA1 in neutrophils, both before and after ACTH treatment and thus suggest that ANXA1 may serve as a marker of glucocorticoid sensitivity. They also reveal a correlation between ANXA1 and the serum gonadotrophins, LH and FSH, and an age-related reduction in ANXA1 expression in lymphocytes.
Key words: glucocorticoids/cortisol • HPA axis • annexin 1 • adrenal dysfunction • inflammation • leukocytes




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