help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH

This version published online on July 5, 2005
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2004-0924
A more recent version of this article appeared on September 1, 2005
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
90/9/5127    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Teegarden, D.
Right arrow Articles by Lyle, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Teegarden, D.
Right arrow Articles by Lyle, R. M.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Calcium
*Osteoporosis

Submitted on May 14, 2004
Accepted on June 21, 2005

Dietary Calcium Intake Protects Women Consuming Oral Contraceptives From Spine and Hip Bone Loss

Dorothy Teegarden PhD*, Pamela Legowski MS, Carolyn W. Gunther PhD, George P. McCabe PhD, Munro Peacock MD, and Roseann M. Lyle PhD

Interdepartmental Nutrition Program, Purdue University; Department of Statistics, Purdue University; Department of Medicine, Indiana University; Department of Health and Kinesiology, Purdue University

Context: It is estimated that 80% of all women have used oral contraceptives (OCP), but OCP use may prevent attainment of maximal peak bone mass in young women and thus increase the risk of osteoporosis later in life.

Objective: This study examined whether increased calcium intake could reduce the detrimental effects of OCP use on bone mass in young women.

Design: One year intervention

Setting: General community

Subjects: Healthy women (n = 154) young (18-30 yr old), with a dietary calcium intake of less than 800 mg/day, and 135 completed the trial.

Intervention: Random assignment to one of three diet intervention groups: 1) control, continue established (< 800 mg/day) dietary intake; 2) medium dairy, increase calcium intake to approximately 1000-1100 mg/day; 3) high dairy, increase calcium intake to approximately 1200-1300 mg/day. Randomization was stratified by OCP use.

Main Outcome Measures: Total body bone mineral density (BMD) and content (BMC); total hip BMD, BMC and bone area; spine BMD, BMC and bone area.

Results: Dairy product intervention positively impacted percent change of total hip BMD and BMC. In addition, dairy product intake prevented a negative percent change in total hip and spine BMD in OCP users.

Conclusion: Dairy product intake, at levels to achieve the recommended intakes of calcium, protected the total hip BMD and spine BMD from loss observed in young healthy women with low calcium intakes who were using OCP.


Key words: calcium • oral contraceptives • bone • women • intervention







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society