| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on ,
Accepted on October 25, 2004
Departments of Obstetrics and Gynecology (RA, YO), Medical Genetics (AK) and Medicine (TMJ), Helsinki University Central Hospital, P.O. Box 140, FIN-00029, Helsinki, Finland
* To whom correspondence should be addressed.
O Ylikorkala, E-mail: olavi.ylikorkala{at}hus.fi
Liver dysfunction may affect the production and release of C-reactive protein (CRP). We designed a double-blind prospective cross-over study involving 40 postmenopausal women with or without a history of intrahepatic cholestasis of pregnancy (ICP), where we compared the basal levels of CRP and their responses to increasing doses of oral and transdermal estradiol (E2), followed by addition of oral medroxyprogesterone acetate (MPA). Serum samples collected at baseline, on the last day of each E2 period and on the last day of the E2 + MPA combination were assayed for CRP, estrogens and liver enzymes. There was no difference in basal CRP between the study groups. Both regimens (oral and transdermal E2) were accompanied by significant rises in estrone and E2 concentrations; the former were 16 times higher during the oral than during the transdermal regimen. Oral E2 elevated CRP dose-dependently and this response was unaffected by a history of ICP or the use of MPA. The activities of liver transaminases varied but were in normal ranges during E2 use, in women with and without a history of ICP. In conclusion, the synthesis of CRP is not affected by a history of ICP. It is readily and dose-dependently stimulated by oral but not by transdermal estradiol as soon as in two weeks.
This article has been cited by other articles:
 |
|
 |
|
  M. Hemelaar, P. Kenemans, C.G. Schalkwijk, D.D.M. Braat, and M.J. van der Mooren No increase in C-reactive protein levels during intranasal compared to oral hormone therapy in healthy post-menopausal women Hum. Reprod., June 1, 2006; 21(6): 1635 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ibanez, C. Valls, and F. de Zegher Discontinuous low-dose flutamide-metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-{alpha} and the neutrophil/lymphocyte ratio Hum. Reprod., February 1, 2006; 21(2): 451 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ropponen, K. Aittomaki, V. Vihma, M. J. Tikkanen, and O. Ylikorkala Effects of Oral and Transdermal Estradiol Administration on Levels of Sex Hormone-Binding Globulin in Postmenopausal Women with and without a History of Intrahepatic Cholestasis of Pregnancy J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3431 - 3434. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
