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Submitted on February 27, 2004
Accepted on September 23, 2004
From the US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, PO Box 9034, Grand Forks, ND 58202-9034; Arkansas Children's Nutrition Center, Department of Pediatrics and Physiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Physics Department, University of North Dakota, Grand Forks, ND
In a controlled feeding study, the effects of substituting 25 g of soy protein for meat on calcium retention and bone biomarkers were determined. Postmenopausal women (n = 13) ate two diets which were similar, except that in one diet 25 g of high-isoflavone soy protein (SOY) was substituted for an equivalent amount of meat protein (CONTROL), for 7 wk each in a randomized crossover design. After 3 wk of equilibration, calcium retention was measured by labeling the 2-d menu with 47Ca, followed by whole body counting for 28 d. Urinary calcium and renal acid excretion were measured at wk 3, 5 and 7. Biomarkers of bone and cardiovascular health were measured at the beginning and end of each diet. Calcium was similarly retained during the CONTROL and SOY diets (d 28, % dose, mean ± pooled SD: 14.1 and 14.0 ± 1.6, respectively). Despite a 15-20% lower renal acid excretion during the SOY diet, urinary calcium loss was unaffected by diet. Diet also did not affect any of the indicators of bone or cardiovascular health. Substitution of 25 g of high isoflavone soy protein for meat, in presence of typical calcium intakes, did not improve or impair calcium retention or indicators of bone and cardiovascular health in postmenopausal women.
Key Words: calcium, absorption, meat, soy, protein, IGF-1, bone, postmenopausal, human, radiotracer, osteoporosis, calciuria, lipid, cholesterol, homocysteine, isoflavones
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