| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808
Address all correspondence and requests for reprints to: Eric Ravussin, 6400 Perkins Road, Baton Rouge, Louisiana 70808. E-mail: ravusse{at}pbrc.edu.
Context: There is debate over the independent and combined effects of dieting and increased physical activity on improving metabolic risk factors (body composition and fat distribution).
Objective: The objective of the study was to conduct a randomized, controlled trial (CALERIE) to test the effect of a 25% energy deficit by diet alone or diet plus exercise for 6 months on body composition and fat distribution.
Design: This was a randomized, controlled trial.
Setting: The study was conducted at an institutional research center.
Participants: Thirty-five of 36 overweight but otherwise healthy participants (16 males, 19 females) completed the study.
Intervention: Participants were randomized to either control (healthy weight maintenance diet, n = 11), caloric restriction (CR; 25% reduction in energy intake, n = 12), or caloric restriction plus exercise (CR+EX; 12.5% reduction in energy intake + 12.5% increase in exercise energy expenditure, n = 12) for 6 months.
Main Outcome Measures: Changes in body composition by dual-energy x-ray absorptiometry and changes in abdominal fat distribution by multislice computed tomography were measured.
Results: The calculated energy deficit across the intervention was not different between CR and CR+EX. Participants lost approximately 10% of body weight (CR: 8.3 ± 0.8, CR+EX: 8.1 ± 0.8 kg, P = 1.00), approximately 24% of fat mass (CR: 5.8 ± 0.6, CR+EX: 6.4 ± 0.6 kg, P = 0.99), and 27% of abdominal visceral fat (CR: 0.9 ± 0.2, CR+EX: 0.8 ± 0.2 kg, P = 1.00). Both whole-body and abdominal fat distribution were not altered by the intervention.
Conclusion: Exercise plays an equivalent role to CR in terms of energy balance; however, it can also improve aerobic fitness, which has other important cardiovascular and metabolic implications.
This article has been cited by other articles:
![]() |
L. M. Redman, J. Rood, S. D. Anton, C. Champagne, S. R. Smith, E. Ravussin, and for the Pennington Comprehensive Assessment of Lon Calorie Restriction and Bone Health in Young, Overweight Individuals Arch Intern Med, September 22, 2008; 168(17): 1859 - 1866. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. M. Janiszewski, T. J. Saunders, and R. Ross Themed Review: Lifestyle Treatment of the Metabolic Syndrome American Journal of Lifestyle Medicine, April 1, 2008; 2(2): 99 - 108. [Abstract] [PDF] |
||||
![]() |
Z. Ungvari, C. Parrado-Fernandez, A. Csiszar, and R. de Cabo Mechanisms Underlying Caloric Restriction and Lifespan Regulation: Implications for Vascular Aging Circ. Res., March 14, 2008; 102(5): 519 - 528. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |