| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Diabetes Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital (F.C., M.Tra., K.B., E.F., M.C., G.A., M.Tro.), and Department of Public Health, University of Turin (A.P., G.C.), 10043 Orbassano, Turin, Italy
Address all correspondence and requests for reprints to: Prof. Mariella Trovati, Diabetes Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano (Turin), Italy. E-mail: mariella.trovati{at}unito.it.
Objective: The influence of postprandial blood glucose on diabetes complications is intensively debated. We aimed to evaluate the predictive role of both fasting and postprandial blood glucose on cardiovascular events in type 2 diabetes and the influence of gender.
Methods: In a population of 529 (284 men and 245 women) consecutive type 2 diabetic patients attending our diabetes clinic, we evaluated the relationships, corrected for cardiovascular risk factors and type of treatment, between cardiovascular events in a 5-yr follow-up and baseline values of hemoglobin A1c (HbA1c) and blood glucose measured: 1) after an overnight fast, 2) after breakfast, 3) after lunch, and 4) before dinner. Continuous variables were categorized into tertiles.
Results: We recorded cardiovascular events in 77 subjects: 54 of 284 men (19%) and 23 of 245 women (9.4%). Univariate analysis indicated that cardiovascular events were associated with increasing age, longer diabetes duration, and higher HbA1c and fibrinogen in men, and higher systolic blood pressure, albumin excretion rate, HbA1c, and all blood glucose values in women. Smoking was more frequent in subjects with events. When all blood glucose values and HbA1c were introduced simultaneously in the models, only blood glucose after lunch predicted cardiovascular events, with hazard ratio of the third tertile vs. the first and the second tertiles greater in women (5.54; confidence interval, 1.45–21.20) than in men (2.12; confidence interval, 1.04–4.32; P < 0.01).
Conclusions: Postprandial, but not fasting, blood glucose is an independent risk factor for cardiovascular events in type 2 diabetes, with a stronger predictive power in women than in men, suggesting that more attention should be paid to postprandial hyperglycemia, particularly in women.
Find additional patient-related information at:
This article has been cited by other articles:
 |
|
 |
|
  J. S. Freeman, D. M. Capuzzi, and K. Rockwell Leveraging Continuous Glucose Monitoring in the Clinical Management of Adjunctive Pramlintide Therapy Clin. Diabetes, July 1, 2008; 26(3): 134 - 137. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hohberg, T. Forst, M. Larbig, M. Safinowski, S. Diessel, S. Hehenwarter, M. M. Weber, T. Schondorf, and A. Pfutzner Effect of Insulin Glulisine on Microvascular Blood Flow and Endothelial Function in the Postprandial State Diabetes Care, May 1, 2008; 31(5): 1021 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Esposito, M. Ciotola, D. Carleo, B. Schisano, L. Sardelli, D. Di Tommaso, L. Misso, F. Saccomanno, A. Ceriello, and D. Giugliano Post-Meal Glucose Peaks at Home Associate with Carotid Intima-Media Thickness in Type 2 Diabetes J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1345 - 1350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L Pearce, M. Noakes, J. Keogh, and P. M Clifton Effect of carbohydrate distribution on postprandial glucose peaks with the use of continuous glucose monitoring in type 2 diabetes Am. J. Clinical Nutrition, March 1, 2008; 87(3): 638 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Bothe, D. M. Franic, R. J. Ingham, and J. H. Davidow Pharmacological Approaches to Stuttering Treatment: Reply to Meline and Harn (2008) Am J Speech Lang Pathol, February 1, 2008; 17(1): 98 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Monnier and C. Colette Glycemic Variability: Should we and can we prevent it? Diabetes Care, February 1, 2008; 31(Supplement_2): S150 - S154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Milicevic, I. Raz, S. D. Beattie, B. N. Campaigne, S. Sarwat, E. Gromniak, I. Kowalska, E. Galic, M. Tan, and M. Hanefeld Natural History of Cardiovascular Disease in Patients With Diabetes: Role of hyperglycemia Diabetes Care, February 1, 2008; 31(Supplement_2): S155 - S160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. O'Keefe, N. M. Gheewala, and J. O. O'Keefe Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health J. Am. Coll. Cardiol., January 22, 2008; 51(3): 249 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Giugliano, A. Ceriello, and K. Esposito Glucose metabolism and hyperglycemia Am. J. Clinical Nutrition, January 1, 2008; 87(1): 217S - 222S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zinman, B. J. Hoogwerf, S. Duran Garcia, D. R. Milton, J. M. Giaconia, D. D. Kim, M. E. Trautmann, and R. G. Brodows The Effect of Adding Exenatide to a Thiazolidinedione in Suboptimally Controlled Type 2 Diabetes: A Randomized Trial Ann Intern Med, April 3, 2007; 146(7): 477 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Mariappan, D. Feliers, S. Mummidi, G. G. Choudhury, and B. S. Kasinath High Glucose, High Insulin, and Their Combination Rapidly Induce Laminin-{beta}1 Synthesis by Regulation of mRNA Translation in Renal Epithelial Cells Diabetes, February 1, 2007; 56(2): 476 - 485. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
