This Article Full Text Full Text (PDF) All Versions of this Article: 91/2/405    most recent Author Manuscript (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by El-Hajj Fuleihan, G. Articles by Vieth, R. Search for Related Content PubMed PubMed Citation Articles by El-Hajj Fuleihan, G. Articles by Vieth, R. Related Collections Pediatric Endocrinology Calcium and Bone Metabolism Metabolism

Effect of Vitamin D Replacement on Musculoskeletal Parameters in School Children: A Randomized Controlled Trial

Calcium Metabolism and Osteoporosis Program (G.E.-H.F., J.M., M.S., M.C., A.A.), Department of Medicine, Department of Pediatrics (M.N., H.K.), School of Health Sciences (H.T.), American University of Beirut, 113-6044 Beirut, Lebanon; and Mt. Sinai Hospital, Toronto University (R.V.), Toronto, Ontario, Canada M5G 1X5

Address all correspondence and requests for reprints to: Dr. Ghada El-Hajj Fuleihan, Calcium Metabolism and Osteoporosis Program, American University of Beirut-Medical Center, Bliss Street, 113-6044 Beirut, Lebanon. E-mail: gf01{at}aub.edu.lb.

Background: Despite the high prevalence of hypovitaminosis D in children and adolescents worldwide, the impact of vitamin D deficiency on skeletal health is unclear.

Methods: One hundred seventy-nine girls, ages 10–17 yr, were randomly assigned to receive weekly oral vitamin D doses of 1,400 IU (equivalent to 200 IU/d) or 14,000 IU (equivalent to 2,000 IU/d) in a double-blind, placebo-controlled, 1-yr protocol. Areal bone mineral density (BMD) and bone mineral content (BMC) at the lumbar spine, hip, forearm, total body, and body composition were measured at baseline and 1 yr. Serum calcium, phosphorus, alkaline phosphatase, and vitamin D metabolites were measured during the study.

Results: In the overall group of girls, lean mass increased significantly in both treatment groups (P 0.05); bone area and total hip BMC increased in the high-dose group (P < 0.02). In premenarcheal girls, lean mass increased significantly in both treatment groups, and there were consistent trends for increments in BMD and/or BMC at several skeletal sites, reaching significance at lumbar spine BMD in the low-dose group and at the trochanter BMC in both treatment groups. There was no significant change in lean mass, BMD, or BMC in postmenarcheal girls.

Conclusions: Vitamin D replacement had a positive impact on musculoskeletal parameters in girls, especially during the premenarcheal period.

This article has been cited by other articles:

				C. L. Wagner, F. R. Greer, and and the Section on Breastfeeding and Committee on Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents Pediatrics, November 1, 2008; 122(5): 1142 - 1152. [Abstract] [Full Text] [PDF]

				C. M. Weaver, L. D. McCabe, G. P. McCabe, M. Braun, B. R. Martin, L. A. DiMeglio, and M. Peacock Vitamin D Status and Calcium Metabolism in Adolescent Black and White Girls on a Range of Controlled Calcium Intakes J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3907 - 3914. [Abstract] [Full Text] [PDF]

				A. Rabbani, S.-M. Alavian, M. E. Motlagh, M. T. H Ashtiani, G. Ardalan, A. Salavati, B. Rabbani, A. Rabbani, S. Shams, and N. Parvaneh Vitamin D Insufficiency among Children and Adolescents Living in Tehran, Iran J Trop Pediatr, September 5, 2008; (2008) fmn078v1. [Abstract] [Full Text] [PDF]

				C. J. Lamberg-Allardt and H. T Viljakainen 25-Hydroxyvitamin D and functional outcomes in adolescents Am. J. Clinical Nutrition, August 1, 2008; 88(2): 534S - 536S. [Abstract] [Full Text] [PDF]

				J. Maalouf, M. Nabulsi, R. Vieth, S. Kimball, R. El-Rassi, Z. Mahfoud, and G. El-Hajj Fuleihan Short- and Long-Term Safety of Weekly High-Dose Vitamin D3 Supplementation in School Children J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2693 - 2701. [Abstract] [Full Text] [PDF]

				T. S. Jones, S. C. Kaste, W. Liu, C. Cheng, W. Yang, K. G. Tantisira, C.-H. Pui, and M. V. Relling CRHR1 Polymorphisms Predict Bone Density in Survivors of Acute Lymphoblastic Leukemia J. Clin. Oncol., June 20, 2008; 26(18): 3031 - 3037. [Abstract] [Full Text] [PDF]

				F. L Weng, J. Shults, M. B Leonard, V. A Stallings, and B. S Zemel Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents Am. J. Clinical Nutrition, July 1, 2007; 86(1): 150 - 158. [Abstract] [Full Text] [PDF]

				C. M Willis, E. M Laing, D. B Hall, D. B Hausman, and R. D Lewis A prospective analysis of plasma 25-hydroxyvitamin D concentrations in white and black prepubertal females in the southeastern United States Am. J. Clinical Nutrition, January 1, 2007; 85(1): 124 - 130. [Abstract] [Full Text] [PDF]

				M. A. Mikati, L. Dib, B. Yamout, R. Sawaya, A. C. Rahi, and G. E.-H. Fuleihan Two randomized vitamin D trials in ambulatory patients on anticonvulsants: Impact on bone Neurology, December 12, 2006; 67(11): 2005 - 2014. [Abstract] [Full Text] [PDF]

				B. W. Hollis and C. L. Wagner Nutritional vitamin D status during pregnancy: reasons for concern. Can. Med. Assoc. J., April 25, 2006; 174(9): 1287 - 1290. [Full Text] [PDF]

				R. Vieth Critique of the Considerations for Establishing the Tolerable Upper Intake Level for Vitamin D: Critical Need for Revision Upwards J. Nutr., April 1, 2006; 136(4): 1117 - 1122. [Abstract] [Full Text] [PDF]