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Diet and Sex Hormones in Boys: Findings from the Dietary Intervention Study in Children

Fox Chase Cancer Center (J.F.D.), Philadelphia, Pennsylvania 19111; Maryland Psychiatric Research Center (R.P.M.), University of Maryland Baltimore, Baltimore, Maryland 21228; Maryland Medical Research Institute (B.A.B., L.A.F.), Baltimore, Maryland 21210; Northwestern University Medical School (L.V.H.), Chicago, Illinois 60611; University of Iowa (L.G.S., R.M.L.), Iowa City, Iowa 52242; Johns Hopkins University (P.O.K.), Baltimore, Maryland 21205; New Jersey Medical School (N.L.L.), Newark, New Jersey 07107; Kaiser Permanente Center for Health Research (V.J.S.), Portland, Oregon 97227; Children’s Hospital (A.R.), New Orleans, Louisiana 70118; Office of Operations, Program Planning, and Scientific Information (S.F.C.), National Institute of Allergy and Infectious Diseases, and Divisions of Cancer Prevention (B.H.P.) and Cancer Epidemiology and Genetics (P.R.T., A.S.), National Cancer Institute, Bethesda, Maryland 20892; Esoterix Endocrinology, Inc. (D.W.C.), Calabasas Hills, California 91301; and Children’s Hospital of Alabama (F.A.F.), Birmingham, Alabama 35233

Address all correspondence and requests for reprints to: Dr. Joanne Dorgan, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111. E-mail: joanne.dorgan{at}fccc.edu.

Context: Diet reportedly alters serum sex hormone concentrations in adults, but little is known about the influence of diet during puberty on these hormones.

Objective: We aimed to determine whether an intervention to lower fat intake during adolescence alters serum sex hormone concentrations and progression through puberty.

Design: In 1990–1997, we conducted an ancillary study to the Dietary Intervention Study in Children, a multicenter, randomized, controlled clinical trial to test the safety and efficacy of a cholesterol-lowering dietary intervention in children.

Participants: Healthy, prepubertal, 8 to 10 yr olds with elevated low-density lipoprotein cholesterol were randomized to usual care or a behavioral intervention. Of 362 randomized Dietary Intervention Study in Children boys, 354 participated in the ancillary study. Eighty-four percent of boys attended last visits when their median time on trial was 7.1 yr.

Intervention: The behavioral intervention continued throughout the duration of the trial and promoted a diet with 28% energy from total fat, less than 8% from saturated fat, 9% or less from polyunsaturated fat, and less than 75 mg cholesterol per 1000 kcal.

Outcome Measures: The main outcome measure for boys formulated before study initiation was non-SHBG bound testosterone concentration. Secondary outcomes included serum total testosterone, dihydrotestosterone, androstenedione, estradiol, estrone, SHBG, and Tanner stage.

Results: There were no significant treatment group differences in boys’ serum hormone levels, SHBG, or Tanner stages at any individual visit or over the course of the trial when evaluated by longitudinal models.

Conclusion: Modest reductions in total fat, saturated fat, and possibly energy intake do not alter progression through puberty or serum sex hormone concentrations in adolescent boys.

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