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Osteoporosis after Solid Organ Transplantation

Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center (N.M.M.), Dallas, Texas 75390; and Department of Medicine, Columbia-Presbyterian Medical Center and College of Physicians and Surgeons, Columbia University (E.S.), New York, New York 10032

Address all correspondence and requests for reprints to: Dr. Elizabeth Shane, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8–864, 630 West 168th Street, New York, New York 10032. E-mail: es54{at}columbia.edu.

With the rapid increase in the number of organs transplanted worldwide and the improved survival of transplant recipients, osteoporosis has emerged as a frequent complication of the transplantation process. In the past decade, the wider recognition of transplantation-related osteoporosis has led to a decrease in the risk of fracture for the individual patient. Nonetheless, fracture rates remain unacceptably high in transplant recipients. This presentation reviews the epidemiology of transplantation-related osteoporosis, the factors contributing to the pathogenesis of this complication, and the evaluation, prevention, and treatment options available for kidney, liver, lung, and heart transplant recipients.

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