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Results of Long-Term Follow-Up after Treatment of Central Precocious Puberty with Leuprorelin Acetate: Evaluation of Effectiveness of Treatment and Recovery of Gonadal Function. The TAP-144-SR Japanese Study Group on Central Precocious Puberty

Department of Endocrinology and Metabolism (T.T., N.M.), National Center for Child Health and Development, Tokyo 157-8535; Department of Pediatrics (H.N.), Graduate School of Medicine, Chiba University, Chiba, Chiba 260-8670; Department of Pediatrics (K.F.), Asahikawa Medical College, Asahikawa 078-8510; Division of Endocrinology and Metabolism (K.T.), Kanagawa Children’s Medical Center, Yokohama 232-8555; Department of Clinical Nursing and Pediatrics (K.O.), Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898; Department of Pediatrics (M.S.), School of Medicine, Toho University, Tokyo 143-8540; and Department of Obstetrics and Gynecology (K.K.), Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan

Address all correspondence and requests for reprints to: Toshiaki Tanaka, Department of Endocrinology and Metabolism, National Center for Child Health and Development, 2-10-1, Okura, Setagaya, Tokyo, 157-8535, Japan. E-mail: tanaka-t{at}ncchd.go.jp.

We evaluated the effect of leuprorelin treatment on adult height (AH) and followed recovery of reproductive function in 63 girls and 13 boys with central precocious puberty (CPP). Mean treatment durations were 3.8 ± 2.0 and 4.1 ± 2.5 yr, and posttreatment follow-up durations were 3.5 ± 1.3 and 2.6 ± 1.1 yr for girls and boys, respectively. AH was 154.5 ± 5.7 cm for girls, and 89.5% of girls reached AH within their target height range. For boys, AH was 163.2 ± 13.0 cm, and 90.9% reached target height range. It appeared that the Bayley-Pinneau method, modified for Japanese children, using a table for advanced bone age (BA), overestimated AH in CPP; and this method, using a table for average BA and projected height for BA, was suitable for prediction of AH in CPP.

Menarche or remenarche occurred in 96.8% of girls at the age of 13.1 ± 1.5 yr. Of 11 girls who contributed urine samples, all seven idiopathic and two organic cases were considered to have ovulation. Serum testosterone levels reached normal adult level in all boys.

In conclusion, long-term leuprorelin treatment for children with CPP improved AH and had no adverse effects on recovery of reproductive function.

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