The Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 9 17a
Copyright © 2006 by The Endocrine Society
Endocrinology & Metabolism News, September 2006
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Endocrine Discovery
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Insufficient evidence was found for the effectiveness of any complementary or alternative treatment for menopausal symptoms in a meta-analysis of 70 trials.
(Arch Intern Med (July 24, 2006) 166(14):1453)
Among individuals with impaired glucose tolerance, common transcription factor 7-like 2 gene variants are associated with increased risk of diabetes due to effects on insulin secretory capacity rather than insulin resistance.
(N Engl J Med (July 20, 2006) 355:241)[Abstract/Free Full Text]
A possible beneficial effect of statin therapy on albuminuria was shown in a meta-analysis of 15 randomized controlled trials.
(Ann Intern Med (July 18, 2006) 145(2):117)
No differences in perinatal mortality or babies with congenital anomalies were identified between mothers with type 1 and type 2 diabetes in a population-based study.
(BMJ (July 22, 2006) 333:177)[Abstract/Free Full Text]
Subclinical hypothyroidism was found to be associated with increased risk of coronary heart disease (OR 1.7, 95% CI 1.3–2.1) in a systematic review.
(Am J Med (July 2006) 119(7):541)
Among 2084 white men, higher estradiol levels were associated with lower risk of subsequent cardiovascular disease in the older men (hazard ratio, 0.86 (CI, 0.78 to 0.96)), whereas no association of serum testosterone or DHEA-S level with incident CVD was seen.
(Ann Intern Med (August 1, 2006) 145(3):176)
Activator-recruited co-factor/Mediator (ARC105) was shown to be a key effector of SREBP-dependent genes’ regulation of lipid homeostasis in metazoans, such as the desaturation of stearic to oleic acid.
(Nature (August 10, 2006) 442(7103):700)
Neuronal tyrosine phosphatase PTP1B knockout mice had lower weight, less adiposity, and increased activity and energy expenditure with hypersensitivity to leptin, suggesting that PTP1B regulates body mass and adiposity primarily through its brain actions.
(Nat Med (August 2006) 12(8):917)
When potential associations of vitamin D receptor gene polymorphisms with bone mineral density and fractures were assessed in 26,242 subjects from a 9-center consortium, only the Cdx2 polymorphism was associated with lesser vertebral fracture risk (–9%; 95% CI, 0% to –18%; P = 0.04), whereas there were no associations between either BMD or fractures and the FokI, BsmI, ApaI, and TaqI polymorphisms.
(Ann Intern Med (August 15, 2006) 145(4):255)
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Endocrine Practice
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New Transportation Security Administration guidelines permit air travelers to carry insulin and related supplies in their carry on baggage, as long as the name on the medication matches the passenger’s ticket. For more information about traveling with diabetes supplies, see: https://diabetes.org/advocacy-and-legalresources/discrimination/public_accommodation/travel.jsp
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Endocrine Education & Training
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Under a new NIH policy, National Research Service Awards will reimburse only 60% of tuition and fees up to $16,000 per year for predoctoral students, $4,500 per year for postdoctoral trainees, and $21,000 per year for dual-degree trainees. However, programs may cover additional tuition expenses by cutting one or more training grant positions. (For more information, see: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-06-090.html)
The Residency Review Committee for Internal Medicine posted a set of frequently asked questions related to program requirements on its web site. (To see the document, go to: http://www.acgme.org/acWebsite/RRC_140/140_SubFAQ2006.pdf)
Postdoctoral students at the University of California are debating whether to unionize with the United Auto Workers. For more information, see Nature (August 10, 2006) 442(7103):609.
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Endocrinologists
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Dr. Liam Murphy, Professor and Director of the Diabetes Research Group at the University of Manitoba, where he investigated the role of insulin-like growth factors and their binding proteins in type 2 diabetes and obesity, died at his home in Winnipeg at age 56.
Ed Horton will receive the Novartis Prize in Diabetes at the 42nd Annual Meeting of the European Association for the Study of Diabetes.
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Milestones in Endocrinology
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75 years ago, Otto Warburg received the Nobel Prize for "his discovery of the nature and mode of action of the respiratory enzyme," i.e., identifying the cytochrome enzymes with their heme group binding molecular oxygen.
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In the Journal 50 Years Ago
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Some new observations on subacute thyroiditis. Skillern PG, Nelson HE, Crile G. J Clin Endocrinol Metab 1956;16:1422–1432.
Six patients were treated with prednisone. One tablet (5 mg) was given four times a day for the first week until all the symptoms were controlled.... In all patients the symptoms were largely ameliorated in less than forty-eight hours after treatment was begun.
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Footnotes
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Readers are encouraged to suggest items for Endocrinology and Metabolism News by email (sherman{at}endo-society.org). Submissions will be considered based on their significance and timeliness.
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