The Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 5 17a
Copyright © 2006 by The Endocrine Society
Endocrinology & Metabolism News May 2006
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Endocrine Discovery
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Insulin did not reduce overall mortality in a randomized control trial of insulin infusion in patients with acute myocardial infarction. However, within three months the insulin-treated group had lower rates of cardiac failure and reinfarction.
(Diabetes Care (April 2006) 29:765)[Abstract/Free Full Text]
In patients with known coronary artery disease, two years of high-intensity statin therapy (rosuvastatin 40 mg/d) achieved significant regression of atherosclerosis by intravascular ultrasound. An average LDL-C of 61 mg/dl was seen, and HDL-C increased by 15%.
(JAMA (April 5, 2006) 295:1556)[Abstract/Free Full Text]
Gatifloxacin treatment of outpatients with or without diabetes was associated with an increased risk of subsequent in-hospital treatment for both hypoglycemia and hyperglycemia in two case control studies.
(N Engl J Med (March 30, 2006) 354:1352)[Abstract/Free Full Text]
Human blood contains several serum leptin-interacting proteins (SLIPs), one of which is C-reactive protein, which directly inhibits leptin binding to its receptors and subsequent leptin signaling in cultured cells. Furthermore, human CRP infusion in ob/ob mice blocked leptin effects on satiety and weight reduction. These findings suggest a role for CRP in leptin resistance.
(Nat Med (April 2006) 12:425)[CrossRef][Medline]
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Endocrinologists
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Alvin Taurog, professor emeritus at UT Southwestern Medical Center and pioneer in thyroid research, died at his Dallas home at age 90. He made important contributions to understanding the role of thyroid peroxidase in thyroid hormone biosynthesis and of antithyroid drug action.
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Milestones in Endocrinology
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One hundred years ago, Sir Henry Dale observed the oxytocic action of posterior pituitary extract, which had a "potent stimulating action on the striated muscle of the uterus" in the cat.
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In the Journal 25 Years Ago
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Increased 1,25 dihydroxycholecalciferol as a cause of abnormal calcium metabolism in sarcoidosis. Koide Y, Kugai N, Kimura S, Fujita T, Yamashita N, Hiramoto, Sukegawa J, Ogata E, Yamashita K. J Clin Endocrinol Metab 1981;52:494 "The present results indicate that increased plasma 1,25 (OH)2D3 levels seem to be the most probable cause of the abnormal calcium metabolism in sarcoidosis."
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Footnotes
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Readers are encouraged to suggest items for Endocrinology and Metabolism News by email (sherman{at}endo-society.org). Submissions will be considered based on their significance and timeliness.
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