Correction
for Illig et al.,
J Clin Endocrinol Metab
89 (10) 5053-5058.
The Journal of Clinical Endocrinology & Metabolism Vol. 90, No. 12 6385
Copyright © 2005 by The Endocrine Society
Announcement and Resource |
Erratum
The article by Illig et al., "Significant Association of the Interleukin-6 Gene Polymorphisms C-174G and A-598G With Type 2 Diabetes" (J Clin Endocrinol Metab 89:5053–5058,2004) contains partially incorrect genotyping data that affect the described association of the IL-6 SNPs C-174G and A-598G with type 2 diabetes. The assignment of sample ID and sample location on the test plates used for the genotyping was incorrect for some study participants. This led to altered genotypes in 222 of the 650 subjects for the SNP IL-6 G-174C and 180 of 607 subjects for the SNP IL-6 A-598G. The correction and completion of the database, which now also includes 46 additional subjects for whom at least one of the genotypes was missing in the first report, attenuated the association of the –174G and –598G alleles with type 2 diabetes. Both –174G and –598G alleles do exhibit a positive trend towards association with type 2 diabetes, but no significant associations remained. With the reference category of –174C/C, conditional logistic regression now yielded an odds ratio (OR) of 1.24 with a 95% confidence interval (CI) of 0.94–1.63 (P = 0.14) for the association with diabetes (original results: 1.35; 1.02–1.79; P = 0.037). The additional consideration of body mass index (BMI) as covariable did not alter the degree of association (OR, 1.25; CI. 0.92–1.70; P = 0.16). Subanalyses for men and women or for lean and more overweight subjects showed no significant differences between the groups. A corrected Table 2 is shown below.
For Tables 3, 4, and 5, which were also based on statistical analyses with the genotype data, only minor differences to the printed manuscript were detected. In Table 3, the impact of the C-174G SNP on BMI is not significant.
The authors regret the error and apologize for any inconvenience that this may have caused.
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TABLE 1. Association of the C-174G SNP with type 2 diabetes: conditional logistic regression on type 2 diabetes patients and controls (subgroup analysis)
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