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Erratum

In the article by Gunton et al., "Metformin Rapidly Increases Insulin Receptor Activation in Human Liver and Signals Preferentially through Insulin-Receptor Substrate-2" (J Clin Endocrinol Metab 88:1323–1332, 2003), Figs. 3 and 5 were reversed. The correct matching of figures and legends is shown below.

View larger version (34K): [in this window] [in a new window]   FIG. 3. Metformin increases IRS-2 phosphorylation within 10 min of treatment but did not affect IRS-1. A, IRS-1 phosphorylation after 30 min of metformin treatment dose response. B, IRS-2 phosphorylation after 30 min of treatment with metformin dose response. C, Quantitation of phospho-IRS-1/total IRS-1. No significant changes (n = 4). D, Quantitation of 6 phospho-IRS-2/total IRS-2 (n = 6). E, Time course of IRS-2 phosphorylation following treatment with 1 µg/ml metformin. F, Quantitation of four metformin time course phospho/total IRS-2 experiments.

View larger version (43K): [in this window] [in a new window]   FIG. 5. IR-KA is increased by metformin. IRs were partially purified from normal human liver and treated with phosphorylation buffer and 32P-ATP for 90 min at 4 C. IRs were eluted and run on 8% SDS-PAGE. The gels were dried and exposed to a phosphor imaging screen. A, Insulin-induced activation of IR partially purified with IRß antibody and protein A beads. B, Metformin-induced activation of IR partially purified with IRß antibody and protein A beads. C, Quantitation of insulin dose response with WGA purification (n = 3). D, Quantitation of insulin dose response with IR antibody purification (n = 3). E, Quantitation of metformin dose response with WGA-purification (n = 3). F, Quantitation of metformin dose response with IR antibody purification (n = 3).

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