Center Feminizing hormone regimens Masculinizing hormone regimes N Academic Hospital Vrije Universiteit, Amsterdam, Netherlands (5 6 7 ) Ethinyl estradiol 100 µg/d or transdermal 17ß-estradiol 100 µg/twice a week and cyproterone acetate 100 mg/d Testosterone esters 250 mg im every 2 wks or testosterone undecanoate 160 mg/d 816 MF293 FM Psychoneuroendocrinology Unit, University of Liège, Liège, Belgium (8 ) Ethinyl estradiol 50–100 µg/d, conjugated equine estrogens 1.25–2.50 mg/d, or estradiol benzoate 25 mg/wk Testosterone 240 mg/d in three doses or testosterone esters 250 mg im every 2–4 wk Unreported Optional, spironolactone 100–200 mg/d or cyproterone acetate 50–100 mg/d Division of Endocrinology, Mount Sinai School of Medicine, New York, NY (9 10 ) Ethinyl estradiol 100 µg/d or conjugated equine estrogens 1.25–2.5 mg/d and medroxyprogesterone acetate 5–10 mg/d for 10 d/month during the first 6 months Testosterone esters (cypionate or enanthate) 250–400 mg im every 2–3 wk 93 FM Optional, spironolactone 100–200 mg/d or cyproterone acetate Department of Endocrinology, University of British Columbia, Vancouver, British Columbia, Canada (11 ) Conjugated equine estrogen 0.625 g/d increased to 5 g/d for 3 of 4 wk and spironolactone 100–200 mg/d gradually increased until testosterone suppression; and medroxyprogesterone 10 mg/d 2 wk/month or continuously if needed Unreported 50 MF Max-Planck-Institute Endocrinological Clinic, Munich, Germany (12 13 ) Estradiol 80–100 mg im every 2 wks, then 17ß-estradiol 2–8 mg/d after 1 yr and cyproterone acetate 100 mg/d for 6–12 months until testosterone is lowered Testosterone esters 250 mg im every 2 wk, reduce in 9–12 months after desired effects to every 2–4 wk 129 total Optional, progesterone 500 mg im two doses 3–4 d apart between testosterone doses Gender Clinic, University of Texas Medical Branch, Galveston, Texas (14 15 ) Ethinyl estradiol 100 µg/d or conjugated equine estrogens 7.5–10 mg/d Testosterone cypionate 200 mg im every 2 wk 60 MF 30 FM Department of Obstetrics and Gynecology, National University of Singapore, Singapore (16 ) Unreported Testosterone esters 250 mg im every 3–4 wk or testosterone cyclopentylpropionate 100 mg im every week 70 FM

All doses are oral unless otherwise noted.

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