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Erratum

A paragraph was inadvertently deleted from Results in the article "Gonadal status in male survivors following childhood brain tumors" by Marianne Schmiegelow, Søren Lassen, Hans Skovgaard Poulsen, Kjeld Schmiegelow, Henrik Hertz, Anna-Maria Andersson, Niels E. Skakkebæk, and Jørn Müller (The Journal of Clinical Endocrinology & Metabolism 86:2446–2452). The corrected paragraph (fourth paragraph) is printed below. The printer regrets the error.

Results

The median and range of BED and endocrinological end points for the 30 patients are summarized in Table 2. For comparison, serum inhibin B levels, the inhibin B/FSH ratio, basal FSH and LH levels, and levels of testosterone and SHBG were measured in normal age-matched male volunteers (n = 347) (median age: 31 yr, range: 22 to 44 yr) and are also included in the table. The normative data for total testicular volumes for adults are in the range of 40–50 mL (25, 26).

In the group of patients who had been treated with CSI (n = 15), there was no significant difference between those who had received CSI + CT (n = 10) and those who had received CSI only (n = 5) with respect to BED to the HP axis or BED to the spine, levels of FSH and peak FSH, levels of inhibin B and the inhibin B/FSH ratio, levels of LH and peak LH, levels of testosterone, SHBG, or total testicular volume.

There was no significant difference between the group of patients who had been treated with RT + CT (n = 13), compared with the group of patients who had been treated with RT only (n = 17) with respect to median BED to the HP axis (80 vs. 78 Gy) but a significant difference with respect to median BED to the spine (51 vs. 0 Gy) (P = 0.02). However, there was no significant difference with respect to median age at RT (8.4 vs. 9.1 yr), or median time of follow-up (16.0 vs. 19.0 yr).

Patients who had received RT + CT, compared with those who had received RT only, had no significant difference in median basal FSH (5.94 vs. 2.90 IU/L) (P = NS); however, there was a significant difference between basal FSH in the RT + CT group, compared with the control group (5.94 vs. 3.17 IU/L; P = 0.007), but no significant difference between basal FSH in the RT-only group, compared with the control group, (2.90 vs. 3.17 IU/L; P = NS; Fig. 1). Furthermore, we found that the RT + CT group, compared with the RT-only group, had a significantly higher median peak FSH response to the GnRH test (8.33 vs. 3.79 IU/L; P = 0.03; Fig. 2) and a significantly lower median inhibin B (86 vs. 270 pg/mL; P = 0.03). The level of inhibin B in the RT + CT group also was significantly lower, compared with the control group (median 86 pg/mL vs.median 215 pg/mL), P = 0.02. However, the inhibin B level in the RT-only group corresponded to normal or near-normal levels in the controls (median 270 pg/mL vs. median 215 pg/mL; Fig. 3). The median inhibin B/FSH ratio was significantly lower in the RT + CT group, compared with the RT-only group (12.8 vs. 107.9; P = 0.04) as well as with the control group (12.8 vs.67.0; P = 0.01), whereas the inhibin B/FSH ratio in the RT-only group corresponded to normal or near-normal levels in our reference population (median 107.9 vs. median 67.0; P= NS; Fig. 4).

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