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Vitamin D Levels and Primary Hyperparathyroidism^d

The Burnham Institute La Jolla, California 92037; and Department of Surgical Sciences Endocrine Unit Uppsala University Hospital SE-75185 Uppsala, Sweden

To the editor:

I am grateful to Drs. Rao and Parfitt for pointing out the misquotation in the article previously published in JCEM (1). In an elegant study they show that serum 25-hydroxyvitamin D levels are related to parathyroid gland weight (2). To my knowledge, serum 1,25-dihydroxyvitamin D3 levels have not been associated with parathyroid gland weight.

With regard to the reduced expression of vitamin D receptors in parathyroid lesions of primary hyperparathyroidism, it is of interest that the reduction in the protein level seems to be more substantial than in the messenger RNA level (1, 3). This suggests that the reduced expression of vitamin D receptors in parathyroid adenomatous cells could be due to both transcriptional and posttranscriptional mechanisms.

Footnotes

^d Received January 25, 2001. Address correspondence to: Tobias Carling, M.D., Ph.D., Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE-75185 Uppsala, Sweden.

References

1. Carling T, Rastad J, Szabo E, Westin G, Akerstrom G. 2000 Reduced parathyroid vitamin D receptor messenger ribonucleic acid levels in primary and secondary hyperparathyroidism. J Clin Endocrinol Metab. 85:2000–2003.[Abstract/Free Full Text]
2. Rao DS, Honasoge M, Divine GW, et al. 2000 Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. J Clin Endocrinol Metab. 85:1054–1058.[Abstract/Free Full Text]
3. Sudhaker Rao D, Han ZH, Phillips ER, Palnitkar S, Parfitt AM. 2000 Reduced vitamin D receptor expression in parathyroid adenomas: implications for pathogenesis. Clin Endocrinol (Oxf). 53:373–381.[CrossRef][Medline]

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